Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair
Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, but all of them have limitations. Therefore, developing novel t...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Cancer Biology & Therapy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15384047.2023.2229958 |
| _version_ | 1797404024444551168 |
|---|---|
| author | Zhen Qian Nannan Feng Anke Geng |
| author_facet | Zhen Qian Nannan Feng Anke Geng |
| author_sort | Zhen Qian |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, but all of them have limitations. Therefore, developing novel therapeutic methods for HCC is in great need. Here, in this study, we found that tanshinone I, a small molecule compound, inhibited the proliferation of HCC cells in a dose-dependent manner. We also observed that Tanshinone I destabilized genomes by inhibiting both NHEJ and HR repair pathways, which are responsible for repairing DNA double strand breaks (DSBs). Mechanistically, this compound suppressed the expression of 53BP1, and the recruitment of RPA2 to DNA damage sites. Importantly, we demonstrated that combining Tanshinone I with radiotherapy exhibited better therapeutic potential for treating HCC. |
| first_indexed | 2024-03-09T02:47:08Z |
| format | Article |
| id | doaj.art-355daf3ee6844353ae498d5642c1ee3a |
| institution | Directory Open Access Journal |
| issn | 1538-4047 1555-8576 |
| language | English |
| last_indexed | 2024-03-09T02:47:08Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj.art-355daf3ee6844353ae498d5642c1ee3a2023-12-05T15:58:14ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762023-12-0124110.1080/15384047.2023.22299582229958Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repairZhen Qian0Nannan Feng1Anke Geng2Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong University School of MedicineTongji UniversityHepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, but all of them have limitations. Therefore, developing novel therapeutic methods for HCC is in great need. Here, in this study, we found that tanshinone I, a small molecule compound, inhibited the proliferation of HCC cells in a dose-dependent manner. We also observed that Tanshinone I destabilized genomes by inhibiting both NHEJ and HR repair pathways, which are responsible for repairing DNA double strand breaks (DSBs). Mechanistically, this compound suppressed the expression of 53BP1, and the recruitment of RPA2 to DNA damage sites. Importantly, we demonstrated that combining Tanshinone I with radiotherapy exhibited better therapeutic potential for treating HCC.http://dx.doi.org/10.1080/15384047.2023.2229958tanshinone ihepatocellular carcinoma (hcc)double strand break repairhomologous recombinationnon-homologous end joining |
| spellingShingle | Zhen Qian Nannan Feng Anke Geng Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair Cancer Biology & Therapy tanshinone i hepatocellular carcinoma (hcc) double strand break repair homologous recombination non-homologous end joining |
| title | Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair |
| title_full | Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair |
| title_fullStr | Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair |
| title_full_unstemmed | Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair |
| title_short | Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair |
| title_sort | tanshinone i suppresses hepatocellular carcinoma cells growth through targeting dna double strand break repair |
| topic | tanshinone i hepatocellular carcinoma (hcc) double strand break repair homologous recombination non-homologous end joining |
| url | http://dx.doi.org/10.1080/15384047.2023.2229958 |
| work_keys_str_mv | AT zhenqian tanshinoneisuppresseshepatocellularcarcinomacellsgrowththroughtargetingdnadoublestrandbreakrepair AT nannanfeng tanshinoneisuppresseshepatocellularcarcinomacellsgrowththroughtargetingdnadoublestrandbreakrepair AT ankegeng tanshinoneisuppresseshepatocellularcarcinomacellsgrowththroughtargetingdnadoublestrandbreakrepair |