Systems Analyses Reveal the Resilience of <named-content content-type="genus-species">Escherichia coli</named-content> Physiology during Accumulation and Export of the Nonnative Organic Acid Citramalate

Systems Analyses Reveal the Resilience of <named-content content-type="genus-species">Escherichia coli</named-content> Physiology during Accumulation and Export of the Nonnative Organic Acid Citramalate

ABSTRACT Productivity of bacterial cell factories is frequently compromised by stresses imposed by recombinant protein synthesis and carbon-to-product conversion, but little is known about these bioprocesses at a systems level. Production of the unnatural metabolite citramalate in Escherichia coli r...

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Bibliographic Details
Main Authors: Joseph Webb, Vicki Springthorpe, Luca Rossoni, David-Paul Minde, Swen Langer, Heather Walker, Amias Alstrom-Moore, Tony Larson, Kathryn Lilley, Graham Eastham, Gill Stephens, Gavin H. Thomas, David J. Kelly, Jeffrey Green
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mSystems
Subjects:
Escherichia coli
bioproduction of chemicals
citramalate
citramalic acid
fed-batch fermentation
lipidomics
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00187-19

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