Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
ObjectiveThis study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting.Materials and methodsWe included 123I-MIBG scans obtained in 35 patients with idiopathic Parkinson’s Disease. Early and late heart-to-mediastinum (H/M)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1073720/full |
| _version_ | 1811160355061104640 |
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| author | Cecilia Boccalini Cecilia Boccalini Cecilia Boccalini Giulia Carli Giulia Carli Emilia Giovanna Vanoli Antoniangela Cocco Alberto Albanese Alberto Albanese Valentina Garibotto Valentina Garibotto Valentina Garibotto Daniela Perani Daniela Perani Daniela Perani |
| author_facet | Cecilia Boccalini Cecilia Boccalini Cecilia Boccalini Giulia Carli Giulia Carli Emilia Giovanna Vanoli Antoniangela Cocco Alberto Albanese Alberto Albanese Valentina Garibotto Valentina Garibotto Valentina Garibotto Daniela Perani Daniela Perani Daniela Perani |
| author_sort | Cecilia Boccalini |
| collection | DOAJ |
| description | ObjectiveThis study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting.Materials and methodsWe included 123I-MIBG scans obtained in 35 patients with idiopathic Parkinson’s Disease. Early and late heart-to-mediastinum (H/M) ratios were calculated from 123I-MIBG images using regions of interest (ROIs) placed over the heart and the mediastinum. The ROIs were derived using two approaches: (i) manually drawn and (ii) semi-automatic fixed-size ROIs using anatomical landmarks. Expert, moderate-expert, and not expert raters applied the ROIs procedures and interpreted the 123I-MIBG images. We evaluated the inter and intra-rater agreements in assessing 123I-MIBG H/M ratios.ResultsA moderate agreement in the raters’ classification of pathological and non-pathological scores emerged regarding early and late H/M ratio values (κ = 0.45 and 0.69 respectively), applying the manual method, while the early and late H/M ratios obtained with the semi-automatic method reached a good agreement among observers (κ = 0.78). Cohen-Kappa values revealed that the semi-automatic method improved the agreement between expert and inexpert raters: the agreement improved from a minimum of 0.29 (fair, for early H/M) and 0.69 (substantial, in late H/M) with the manual method, to 0.90 (perfect, in early H/M) and 0.87 (perfect, in late H/M) with the semi-automatic method.ConclusionThe use of the semi-automatic method improves the agreement among raters in classifying’ H/M ratios as pathological or non-pathological, namely for inexpert readers. These results have important implications for semi-quantitative assessment of 123I-MIBG images in clinical routine. |
| first_indexed | 2024-04-10T05:55:57Z |
| format | Article |
| id | doaj.art-355f402264f14f899fd89f384c1495d0 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T05:55:57Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-355f402264f14f899fd89f384c1495d02023-03-03T15:34:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.10737201073720Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s diseaseCecilia Boccalini0Cecilia Boccalini1Cecilia Boccalini2Giulia Carli3Giulia Carli4Emilia Giovanna Vanoli5Antoniangela Cocco6Alberto Albanese7Alberto Albanese8Valentina Garibotto9Valentina Garibotto10Valentina Garibotto11Daniela Perani12Daniela Perani13Daniela Perani14School of Psychology, Vita-Salute San Raffaele University, Milan, ItalyIn vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, ItalyLaboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, SwitzerlandIn vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, ItalyDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, NetherlandsNuclear Medicine Unit, San Raffaele Hospital, Milan, ItalyDepartment of Neurology, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Humanitas Research Hospital, Milan, ItalyDepartment of Neurology, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Humanitas Research Hospital, Milan, ItalyDepartment of Neuroscience, Catholic University, Milan, ItalyLaboratory of Neuroimaging and Innovative Molecular Tracers (NIMTlab), Geneva University Neurocenter and Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDivision of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, SwitzerlandCenter for Biomedical Imaging, Geneva, SwitzerlandSchool of Psychology, Vita-Salute San Raffaele University, Milan, ItalyIn vivo Human Molecular and Structural Neuroimaging Unit, Division of Neuroscience, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) San Raffaele Scientific Institute, Milan, ItalyNuclear Medicine Unit, San Raffaele Hospital, Milan, ItalyObjectiveThis study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting.Materials and methodsWe included 123I-MIBG scans obtained in 35 patients with idiopathic Parkinson’s Disease. Early and late heart-to-mediastinum (H/M) ratios were calculated from 123I-MIBG images using regions of interest (ROIs) placed over the heart and the mediastinum. The ROIs were derived using two approaches: (i) manually drawn and (ii) semi-automatic fixed-size ROIs using anatomical landmarks. Expert, moderate-expert, and not expert raters applied the ROIs procedures and interpreted the 123I-MIBG images. We evaluated the inter and intra-rater agreements in assessing 123I-MIBG H/M ratios.ResultsA moderate agreement in the raters’ classification of pathological and non-pathological scores emerged regarding early and late H/M ratio values (κ = 0.45 and 0.69 respectively), applying the manual method, while the early and late H/M ratios obtained with the semi-automatic method reached a good agreement among observers (κ = 0.78). Cohen-Kappa values revealed that the semi-automatic method improved the agreement between expert and inexpert raters: the agreement improved from a minimum of 0.29 (fair, for early H/M) and 0.69 (substantial, in late H/M) with the manual method, to 0.90 (perfect, in early H/M) and 0.87 (perfect, in late H/M) with the semi-automatic method.ConclusionThe use of the semi-automatic method improves the agreement among raters in classifying’ H/M ratios as pathological or non-pathological, namely for inexpert readers. These results have important implications for semi-quantitative assessment of 123I-MIBG images in clinical routine.https://www.frontiersin.org/articles/10.3389/fmed.2022.1073720/fullParkinson’s diseaseMIBG scintigraphyH/M ratiosmanual-drawing approachsemi-automatic fixed-size ROIs |
| spellingShingle | Cecilia Boccalini Cecilia Boccalini Cecilia Boccalini Giulia Carli Giulia Carli Emilia Giovanna Vanoli Antoniangela Cocco Alberto Albanese Alberto Albanese Valentina Garibotto Valentina Garibotto Valentina Garibotto Daniela Perani Daniela Perani Daniela Perani Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease Frontiers in Medicine Parkinson’s disease MIBG scintigraphy H/M ratios manual-drawing approach semi-automatic fixed-size ROIs |
| title | Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease |
| title_full | Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease |
| title_fullStr | Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease |
| title_full_unstemmed | Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease |
| title_short | Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease |
| title_sort | manual and semi automated approaches to mibg myocardial scintigraphy in patients with parkinson s disease |
| topic | Parkinson’s disease MIBG scintigraphy H/M ratios manual-drawing approach semi-automatic fixed-size ROIs |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1073720/full |
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