Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system

Paternal developmental thyrotoxicosis disrupts neonatal leptin leading to increased adiposity and altered physiology of the melanocortin system

BackgroundThe genetic code does not fully explain individual variability and inheritance of susceptibility to endocrine conditions, suggesting the contribution of epigenetic factors acting across generations.MethodsWe used a mouse model of developmental thyrotoxicosis (Dio3-/- mouse) to analyze endo...

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Bibliographic Details
Main Authors:	Maria Elena Martinez, Zhaofei Wu, Arturo Hernandez
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Series:	Frontiers in Endocrinology
Subjects:	thyroid hormone intergenerational epigenetics adiposity hypothalamic-pituitary-thyroid axis fasting leptin
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1210414/full

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