A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL m...

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Bibliographic Details
Main Authors:	Elizabeth X Kwan, Eric J Foss, Scott Tsuchiyama, Gina M Alvino, Leonid Kruglyak, Matt Kaeberlein, M K Raghuraman, Bonita J Brewer, Brian K Kennedy, Antonio Bedalov
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC3591295?pdf=render

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