Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases
Cardiovascular dysfunction induced by sepsis is one of the most common phenotypes of cardiovascular diseases (CVDs), which is closely related to the high mortality of sepsis and is an urgent health problem to be solved worldwide. Unfortunately, the exact pathogenesis and pathophysiology of sepsis-in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-07-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/24/7/10.31083/j.rcm2407214 |
| _version_ | 1797768886654861312 |
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| author | Wei Xiong Shiyan Feng Yanhua Zhao Xinquan Liu Jian Gong |
| author_facet | Wei Xiong Shiyan Feng Yanhua Zhao Xinquan Liu Jian Gong |
| author_sort | Wei Xiong |
| collection | DOAJ |
| description | Cardiovascular dysfunction induced by sepsis is one of the most common phenotypes of cardiovascular diseases (CVDs), which is closely related to the high mortality of sepsis and is an urgent health problem to be solved worldwide. Unfortunately, the exact pathogenesis and pathophysiology of sepsis-induced cardiovascular dysfunction are not clear. As a research hotspot in recent years, competing endogenous RNA (ceRNA) networks are involved in the modulation of the pathophysiological progression of many diseases, including sepsis-related CVDs. Both long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) can specifically bind to microRNAs (miRNAs) as ceRNAs to target messenger RNAs (mRNAs), forming a ceRNA network composed of lncRNA/circRNA-miRNA-mRNA. This review demonstrates the potential regulatory mechanism of the ceRNA networks in sepsis-induced cardiovascular toxicity, hoping to provide novel therapeutic strategies and monitoring targets for sepsis-related CVDs. |
| first_indexed | 2024-03-12T20:59:49Z |
| format | Article |
| id | doaj.art-356289f2e7be4cb09f795fc7566e8ff0 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-03-12T20:59:49Z |
| publishDate | 2023-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-356289f2e7be4cb09f795fc7566e8ff02023-07-31T08:26:15ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-07-0124721410.31083/j.rcm2407214S1530-6550(23)00895-5Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular DiseasesWei Xiong0Shiyan Feng1Yanhua Zhao2Xinquan Liu3Jian Gong4Laboratory of Clinical Research, Ziyang People’s Hospital, Ziyang Hospital of Sichuan Provincial People’s Hospital, 641300 Ziyang, Sichuan, ChinaLaboratory of Clinical Research, Ziyang People’s Hospital, Ziyang Hospital of Sichuan Provincial People’s Hospital, 641300 Ziyang, Sichuan, ChinaLaboratory of Clinical Research, Ziyang People’s Hospital, Ziyang Hospital of Sichuan Provincial People’s Hospital, 641300 Ziyang, Sichuan, ChinaLaboratory of Clinical Research, Ziyang People’s Hospital, Ziyang Hospital of Sichuan Provincial People’s Hospital, 641300 Ziyang, Sichuan, ChinaLaboratory of Clinical Research, Ziyang People’s Hospital, Ziyang Hospital of Sichuan Provincial People’s Hospital, 641300 Ziyang, Sichuan, ChinaCardiovascular dysfunction induced by sepsis is one of the most common phenotypes of cardiovascular diseases (CVDs), which is closely related to the high mortality of sepsis and is an urgent health problem to be solved worldwide. Unfortunately, the exact pathogenesis and pathophysiology of sepsis-induced cardiovascular dysfunction are not clear. As a research hotspot in recent years, competing endogenous RNA (ceRNA) networks are involved in the modulation of the pathophysiological progression of many diseases, including sepsis-related CVDs. Both long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) can specifically bind to microRNAs (miRNAs) as ceRNAs to target messenger RNAs (mRNAs), forming a ceRNA network composed of lncRNA/circRNA-miRNA-mRNA. This review demonstrates the potential regulatory mechanism of the ceRNA networks in sepsis-induced cardiovascular toxicity, hoping to provide novel therapeutic strategies and monitoring targets for sepsis-related CVDs.https://www.imrpress.com/journal/RCM/24/7/10.31083/j.rcm2407214cardiovascularsepsiscompeting endogenous rnalong noncoding rnacircular rnamicrorna |
| spellingShingle | Wei Xiong Shiyan Feng Yanhua Zhao Xinquan Liu Jian Gong Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases Reviews in Cardiovascular Medicine cardiovascular sepsis competing endogenous rna long noncoding rna circular rna microrna |
| title | Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases |
| title_full | Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases |
| title_fullStr | Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases |
| title_full_unstemmed | Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases |
| title_short | Revealing Landscape of Competing Endogenous RNA Networks in Sepsis-Induced Cardiovascular Diseases |
| title_sort | revealing landscape of competing endogenous rna networks in sepsis induced cardiovascular diseases |
| topic | cardiovascular sepsis competing endogenous rna long noncoding rna circular rna microrna |
| url | https://www.imrpress.com/journal/RCM/24/7/10.31083/j.rcm2407214 |
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