Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies
In recent years, more scientific data have pointed out the close connection between intestinal microbial community, nutritional habits, lifestyle, and the appearance of various affections located at certain anatomical systems. Gut dysbiosis enhances the formation and accumulation of specific metabol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/15/9/548 |
| _version_ | 1797576528938139648 |
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| author | Laura Mitrea Mădălina Medeleanu Carmen-Rodica Pop Ancuța-Mihaela Rotar Dan-Cristian Vodnar |
| author_facet | Laura Mitrea Mădălina Medeleanu Carmen-Rodica Pop Ancuța-Mihaela Rotar Dan-Cristian Vodnar |
| author_sort | Laura Mitrea |
| collection | DOAJ |
| description | In recent years, more scientific data have pointed out the close connection between intestinal microbial community, nutritional habits, lifestyle, and the appearance of various affections located at certain anatomical systems. Gut dysbiosis enhances the formation and accumulation of specific metabolites with toxic potential that induce the appearance of kidney-associated illnesses. Intestinal microbes are involved in the degradation of food, drugs, or other ingested products that lead to the formation of various metabolites that end up in renal tissue. Over the last few years, the possibilities of modulating the gut microbiota for the biosynthesis of targeted compounds with bioactive properties for reducing the risk of chronic illness development were investigated. In this regard, the present narrative review provides an overview of the scientific literature across the last decade considering the relationship between bioactive compounds, pre-, pro-, and post-biotics, uremic toxicity, and kidney-associated affections, and the possibility of alleviating the accumulation and the negative effects of uremic toxins into the renal system. |
| first_indexed | 2024-03-10T21:53:25Z |
| format | Article |
| id | doaj.art-35648dfa8fd54d3dbcbf74948be554df |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T21:53:25Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-35648dfa8fd54d3dbcbf74948be554df2023-11-19T13:15:53ZengMDPI AGToxins2072-66512023-09-0115954810.3390/toxins15090548Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible TherapiesLaura Mitrea0Mădălina Medeleanu1Carmen-Rodica Pop2Ancuța-Mihaela Rotar3Dan-Cristian Vodnar4Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, RomaniaIn recent years, more scientific data have pointed out the close connection between intestinal microbial community, nutritional habits, lifestyle, and the appearance of various affections located at certain anatomical systems. Gut dysbiosis enhances the formation and accumulation of specific metabolites with toxic potential that induce the appearance of kidney-associated illnesses. Intestinal microbes are involved in the degradation of food, drugs, or other ingested products that lead to the formation of various metabolites that end up in renal tissue. Over the last few years, the possibilities of modulating the gut microbiota for the biosynthesis of targeted compounds with bioactive properties for reducing the risk of chronic illness development were investigated. In this regard, the present narrative review provides an overview of the scientific literature across the last decade considering the relationship between bioactive compounds, pre-, pro-, and post-biotics, uremic toxicity, and kidney-associated affections, and the possibility of alleviating the accumulation and the negative effects of uremic toxins into the renal system.https://www.mdpi.com/2072-6651/15/9/548gut microbiotadysbiosisuremic toxinskidney disordersprebioticsprobiotics |
| spellingShingle | Laura Mitrea Mădălina Medeleanu Carmen-Rodica Pop Ancuța-Mihaela Rotar Dan-Cristian Vodnar Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies Toxins gut microbiota dysbiosis uremic toxins kidney disorders prebiotics probiotics |
| title | Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies |
| title_full | Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies |
| title_fullStr | Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies |
| title_full_unstemmed | Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies |
| title_short | Biotics (Pre-, Pro-, Post-) and Uremic Toxicity: Implications, Mechanisms, and Possible Therapies |
| title_sort | biotics pre pro post and uremic toxicity implications mechanisms and possible therapies |
| topic | gut microbiota dysbiosis uremic toxins kidney disorders prebiotics probiotics |
| url | https://www.mdpi.com/2072-6651/15/9/548 |
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