Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease
BackgroundThe endothelial glycocalyx (EG) is essential for maintaining microvascular homeostasis. However, the relationship between the EG and coronary microcirculation remains to be elucidated. One of the main components of EG is syndecan-1, and its shedding has been claimed to represent the state...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.950102/full |
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| author | Yang Liu Yang Liu Yang Liu Si Chen Shaoyan Liu Guoqiang Sun Zhijun Sun Hongbin Liu Hongbin Liu Hongbin Liu Hongbin Liu |
| author_facet | Yang Liu Yang Liu Yang Liu Si Chen Shaoyan Liu Guoqiang Sun Zhijun Sun Hongbin Liu Hongbin Liu Hongbin Liu Hongbin Liu |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | BackgroundThe endothelial glycocalyx (EG) is essential for maintaining microvascular homeostasis. However, the relationship between the EG and coronary microcirculation remains to be elucidated. One of the main components of EG is syndecan-1, and its shedding has been claimed to represent the state of the EG. In this study, we aimed to analyze the association between syndecan-1 and the coronary microcirculation.MethodsWe enrolled suspected coronary artery disease (CAD) patients who consecutively underwent coronary angiography (CAG) and angiography-based analysis of physiological indices in the left anterior descending artery (LAD). Serum syndecan-1 was measured by enzyme-linked immunosorbent assay (ELISA). The coronary microcirculation was evaluated by the presence of coronary microvascular dysfunction (CMD) and an impaired microvascular vasodilatory capacity (IMVC), which were quantified by an angiography-derived index of microcirculatory resistance (IMRangio) in the maximum hyperemic state (H-IMRangio) induced by adenosine triphosphate and the ratio (RRRangio) of IMRangio in the non-hyperemic phase to H-IMRangio, respectively.ResultsA total of 528 patients were enrolled in this study. There was no difference in epicardial coronary complexity between patients with high syndecan-1 (HSG) and low syndecan-1 (LSG) levels grouped by the median concentration of syndecan-1 (SYNTAX: 7[3, 10] vs. 9[4, 12], P = 0.15). However, H-IMRangio and RRRangio were different between the LSG and HSG groups (H-IMRangio: 23.64 ± 6.28 vs. 27.67 ± 5.59, P < 0.01; RRRangio: 1.74[1.46, 2.08] vs. 1.55[1.34, 1.72], P < 0.01). Patients with CMD (H-IMRangio > 25) and patients with IMVC (RRRangio below the median value) both had higher syndecan-1 levels (CMD: 86.44 ± 54.15 vs. 55.2 ± 43.72, P < 0.01; IMVC: 83.86 ± 55.41 vs. 59.68 ± 45.06, P < 0.01). After adjustment for confounding factors, HSG remained associated with the presence of CMD and IMVC (CMD: odds ratio [OR]: 2.769, P < 0.01; IMVC: OR: 1.908, P < 0.01).ConclusionHigh levels of syndecan-1 are independently associated with the presence of CMD and IMVC among patients with suspected CAD. |
| first_indexed | 2024-12-10T11:25:30Z |
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| publishDate | 2022-09-01 |
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| spelling | doaj.art-3567b1636e4e46a78b124c1c087750712022-12-22T01:50:45ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.950102950102Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery diseaseYang Liu0Yang Liu1Yang Liu2Si Chen3Shaoyan Liu4Guoqiang Sun5Zhijun Sun6Hongbin Liu7Hongbin Liu8Hongbin Liu9Hongbin Liu10Medical School of Chinese People’s Liberation Army, Beijing, ChinaDepartment of Cardiology, Second Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaNational Clinical Research Center for Geriatric Diseases, Beijing, ChinaDepartment of Cardiology, First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Cardiology, Yantai Municipal Laiyang Central Hospital, Yantai, ChinaDepartment of Cardiology, Sixth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Cardiology, Sixth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaMedical School of Chinese People’s Liberation Army, Beijing, ChinaDepartment of Cardiology, Second Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaNational Clinical Research Center for Geriatric Diseases, Beijing, ChinaBeijing Key Laboratory of Chronic Heart Failure Precision Medicine, Beijing, ChinaBackgroundThe endothelial glycocalyx (EG) is essential for maintaining microvascular homeostasis. However, the relationship between the EG and coronary microcirculation remains to be elucidated. One of the main components of EG is syndecan-1, and its shedding has been claimed to represent the state of the EG. In this study, we aimed to analyze the association between syndecan-1 and the coronary microcirculation.MethodsWe enrolled suspected coronary artery disease (CAD) patients who consecutively underwent coronary angiography (CAG) and angiography-based analysis of physiological indices in the left anterior descending artery (LAD). Serum syndecan-1 was measured by enzyme-linked immunosorbent assay (ELISA). The coronary microcirculation was evaluated by the presence of coronary microvascular dysfunction (CMD) and an impaired microvascular vasodilatory capacity (IMVC), which were quantified by an angiography-derived index of microcirculatory resistance (IMRangio) in the maximum hyperemic state (H-IMRangio) induced by adenosine triphosphate and the ratio (RRRangio) of IMRangio in the non-hyperemic phase to H-IMRangio, respectively.ResultsA total of 528 patients were enrolled in this study. There was no difference in epicardial coronary complexity between patients with high syndecan-1 (HSG) and low syndecan-1 (LSG) levels grouped by the median concentration of syndecan-1 (SYNTAX: 7[3, 10] vs. 9[4, 12], P = 0.15). However, H-IMRangio and RRRangio were different between the LSG and HSG groups (H-IMRangio: 23.64 ± 6.28 vs. 27.67 ± 5.59, P < 0.01; RRRangio: 1.74[1.46, 2.08] vs. 1.55[1.34, 1.72], P < 0.01). Patients with CMD (H-IMRangio > 25) and patients with IMVC (RRRangio below the median value) both had higher syndecan-1 levels (CMD: 86.44 ± 54.15 vs. 55.2 ± 43.72, P < 0.01; IMVC: 83.86 ± 55.41 vs. 59.68 ± 45.06, P < 0.01). After adjustment for confounding factors, HSG remained associated with the presence of CMD and IMVC (CMD: odds ratio [OR]: 2.769, P < 0.01; IMVC: OR: 1.908, P < 0.01).ConclusionHigh levels of syndecan-1 are independently associated with the presence of CMD and IMVC among patients with suspected CAD.https://www.frontiersin.org/articles/10.3389/fcvm.2022.950102/fullendothelial glycocalyxsyndecan-1coronary microcirculationcoronary microvascular dysfunctionimpaired microvascular vasodilatory capacityangiography-derived index of microcirculatory resistance |
| spellingShingle | Yang Liu Yang Liu Yang Liu Si Chen Shaoyan Liu Guoqiang Sun Zhijun Sun Hongbin Liu Hongbin Liu Hongbin Liu Hongbin Liu Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease Frontiers in Cardiovascular Medicine endothelial glycocalyx syndecan-1 coronary microcirculation coronary microvascular dysfunction impaired microvascular vasodilatory capacity angiography-derived index of microcirculatory resistance |
| title | Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease |
| title_full | Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease |
| title_fullStr | Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease |
| title_full_unstemmed | Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease |
| title_short | Association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography-derived index of microcirculatory resistance in patients with suspected coronary artery disease |
| title_sort | association of endothelial glycocalyx shedding and coronary microcirculation assessed by an angiography derived index of microcirculatory resistance in patients with suspected coronary artery disease |
| topic | endothelial glycocalyx syndecan-1 coronary microcirculation coronary microvascular dysfunction impaired microvascular vasodilatory capacity angiography-derived index of microcirculatory resistance |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.950102/full |
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