Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease
BackgroundPrevious reports showed that some patients with minimal change disease (MCD) had high serum immunoglobulin E (IgE) levels. This study aimed to explore the proportion of MCD patients with high serum IgE levels and evaluate the correlation between serum IgE levels and MCD remission and relap...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.840857/full |
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| author | Heng Li Heng Li Heng Li Heng Li Heng Li Lefeng Wang Lefeng Wang Lefeng Wang Lefeng Wang Lefeng Wang Xiayu Li Xiayu Li Xiayu Li Xiayu Li Xiayu Li Wenqing Chen Wenqing Chen Wenqing Chen Wenqing Chen Wenqing Chen Ying Zhang Ying Zhang Ying Zhang Ying Zhang Ying Zhang Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen |
| author_facet | Heng Li Heng Li Heng Li Heng Li Heng Li Lefeng Wang Lefeng Wang Lefeng Wang Lefeng Wang Lefeng Wang Xiayu Li Xiayu Li Xiayu Li Xiayu Li Xiayu Li Wenqing Chen Wenqing Chen Wenqing Chen Wenqing Chen Wenqing Chen Ying Zhang Ying Zhang Ying Zhang Ying Zhang Ying Zhang Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen |
| author_sort | Heng Li |
| collection | DOAJ |
| description | BackgroundPrevious reports showed that some patients with minimal change disease (MCD) had high serum immunoglobulin E (IgE) levels. This study aimed to explore the proportion of MCD patients with high serum IgE levels and evaluate the correlation between serum IgE levels and MCD remission and relapse.MethodsThis study enrolled 222 new-onset patients with renal biopsy-confirmed MCD from October 2012 to October 2019 at the First Affiliated Hospital of Zhejiang University in Hangzhou, China. Patients’ demographics and clinical parameters were analyzed.ResultsThe results indicated that 70.3% of 222 MCD patients had high serum IgE levels (IgE > 100.0 IU/mL). Moreover, 134 patients were treated with glucocorticoids alone and divided into the low- and high-IgE groups, according to the median serum IgE level (523.5 IU/mL). The mean time to complete remission of the low- and high-IgE groups was 29.0 ± 2.2 and 45.7 ± 4.2 days, respectively (log-rank test; P = 0.002). The mean time to total remission was 19.1 ± 1.4 and 31.6 ± 3.2 days of the low- and high-IgE groups, respectively (log-rank test; P < 0.001). The mean time to first relapse in the low- and high-IgE groups was 701.2 ± 65.0 and 425.0 ± 52.6 days, respectively (log-rank test; P = 0.002). Serum IgE ≥ 523.5 IU/mL was an independent correlation factor affecting the patients’ remission and relapse.ConclusionSerum IgE level was an independent correlation factor for MCD remission and relapse. MCD patients with high serum IgE levels were prone to delayed remissions and early relapses. |
| first_indexed | 2024-12-13T14:21:52Z |
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| id | doaj.art-3567d10704fe47d4aac93f01e9fc2f0e |
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| language | English |
| last_indexed | 2024-12-13T14:21:52Z |
| publishDate | 2022-03-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-3567d10704fe47d4aac93f01e9fc2f0e2022-12-21T23:42:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-03-011310.3389/fimmu.2022.840857840857Serum IgE Levels Are Associated With the Prognosis of Minimal Change DiseaseHeng Li0Heng Li1Heng Li2Heng Li3Heng Li4Lefeng Wang5Lefeng Wang6Lefeng Wang7Lefeng Wang8Lefeng Wang9Xiayu Li10Xiayu Li11Xiayu Li12Xiayu Li13Xiayu Li14Wenqing Chen15Wenqing Chen16Wenqing Chen17Wenqing Chen18Wenqing Chen19Ying Zhang20Ying Zhang21Ying Zhang22Ying Zhang23Ying Zhang24Jianghua Chen25Jianghua Chen26Jianghua Chen27Jianghua Chen28Jianghua Chen29Kidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, ChinaNational Key Clinical Department of Kidney Diseases, Hangzhou, ChinaInstitute of Nephrology, Zhejiang University, Hangzhou, ChinaZhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, ChinaNational Key Clinical Department of Kidney Diseases, Hangzhou, ChinaInstitute of Nephrology, Zhejiang University, Hangzhou, ChinaZhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, ChinaNational Key Clinical Department of Kidney Diseases, Hangzhou, ChinaInstitute of Nephrology, Zhejiang University, Hangzhou, ChinaZhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, ChinaNational Key Clinical Department of Kidney Diseases, Hangzhou, ChinaInstitute of Nephrology, Zhejiang University, Hangzhou, ChinaZhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, ChinaNational Key Clinical Department of Kidney Diseases, Hangzhou, ChinaInstitute of Nephrology, Zhejiang University, Hangzhou, ChinaZhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaKidney Disease Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, ChinaNational Key Clinical Department of Kidney Diseases, Hangzhou, ChinaInstitute of Nephrology, Zhejiang University, Hangzhou, ChinaZhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, ChinaBackgroundPrevious reports showed that some patients with minimal change disease (MCD) had high serum immunoglobulin E (IgE) levels. This study aimed to explore the proportion of MCD patients with high serum IgE levels and evaluate the correlation between serum IgE levels and MCD remission and relapse.MethodsThis study enrolled 222 new-onset patients with renal biopsy-confirmed MCD from October 2012 to October 2019 at the First Affiliated Hospital of Zhejiang University in Hangzhou, China. Patients’ demographics and clinical parameters were analyzed.ResultsThe results indicated that 70.3% of 222 MCD patients had high serum IgE levels (IgE > 100.0 IU/mL). Moreover, 134 patients were treated with glucocorticoids alone and divided into the low- and high-IgE groups, according to the median serum IgE level (523.5 IU/mL). The mean time to complete remission of the low- and high-IgE groups was 29.0 ± 2.2 and 45.7 ± 4.2 days, respectively (log-rank test; P = 0.002). The mean time to total remission was 19.1 ± 1.4 and 31.6 ± 3.2 days of the low- and high-IgE groups, respectively (log-rank test; P < 0.001). The mean time to first relapse in the low- and high-IgE groups was 701.2 ± 65.0 and 425.0 ± 52.6 days, respectively (log-rank test; P = 0.002). Serum IgE ≥ 523.5 IU/mL was an independent correlation factor affecting the patients’ remission and relapse.ConclusionSerum IgE level was an independent correlation factor for MCD remission and relapse. MCD patients with high serum IgE levels were prone to delayed remissions and early relapses.https://www.frontiersin.org/articles/10.3389/fimmu.2022.840857/fullminimal change diseaseserum IgE levelremissionrelapserisk factor |
| spellingShingle | Heng Li Heng Li Heng Li Heng Li Heng Li Lefeng Wang Lefeng Wang Lefeng Wang Lefeng Wang Lefeng Wang Xiayu Li Xiayu Li Xiayu Li Xiayu Li Xiayu Li Wenqing Chen Wenqing Chen Wenqing Chen Wenqing Chen Wenqing Chen Ying Zhang Ying Zhang Ying Zhang Ying Zhang Ying Zhang Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Jianghua Chen Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease Frontiers in Immunology minimal change disease serum IgE level remission relapse risk factor |
| title | Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease |
| title_full | Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease |
| title_fullStr | Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease |
| title_full_unstemmed | Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease |
| title_short | Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease |
| title_sort | serum ige levels are associated with the prognosis of minimal change disease |
| topic | minimal change disease serum IgE level remission relapse risk factor |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.840857/full |
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