Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells
The characteristic features of nanomaterials provide rich opportunities for a broad range of applications due to their different physicochemical properties. Nanocolloidal silver and graphenic carbon materials differ in most physicochemical characteristics, except for their nanodimensions. Since ther...
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| Online Access: | https://www.mdpi.com/1996-1944/13/9/2159 |
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| author | Anna Hotowy Marta Grodzik Marlena Zielińska-Górska Natalia Chojnacka Natalia Kurantowicz Sławomir Dyjak Barbara Strojny Marta Kutwin André Chwalibog Ewa Sawosz |
| author_facet | Anna Hotowy Marta Grodzik Marlena Zielińska-Górska Natalia Chojnacka Natalia Kurantowicz Sławomir Dyjak Barbara Strojny Marta Kutwin André Chwalibog Ewa Sawosz |
| author_sort | Anna Hotowy |
| collection | DOAJ |
| description | The characteristic features of nanomaterials provide rich opportunities for a broad range of applications due to their different physicochemical properties. Nanocolloidal silver and graphenic carbon materials differ in most physicochemical characteristics, except for their nanodimensions. Since there is a growing demand for stem cell therapies for coronary disorders, examining cardiac progenitor cells (CPC) in terms of their response to nanostructure treatment seems to be a reasonable approach. Morphological studies and viability assessments were performed with CPC in vitro, treated with small concentrations of silver nanoparticles (AgNP), hierarchical nanoporous graphenic carbon (HNC) and their mixtures. A viability test confirmed the morphological assessment of CPC treated with AgNP and HNC; moreover, the action of both nanomaterials was time-dependent and dose-dependent. For AgNP, between the two of the applied concentrations lies a border between their potential beneficial effect and toxicity. For HNC, at a lower concentration, strong stimulation of cell viability was noted, whereas a higher dosage activated their differentiation. It is necessary to perform further research examining the mechanisms of the action of AgNP and especially of unexplored HNC, and their mixtures, on CPC and other cells. |
| first_indexed | 2024-03-10T19:59:10Z |
| format | Article |
| id | doaj.art-356955a213d9424583355f0f17a7cadd |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T19:59:10Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-356955a213d9424583355f0f17a7cadd2023-11-19T23:42:45ZengMDPI AGMaterials1996-19442020-05-01139215910.3390/ma13092159Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor CellsAnna Hotowy0Marta Grodzik1Marlena Zielińska-Górska2Natalia Chojnacka3Natalia Kurantowicz4Sławomir Dyjak5Barbara Strojny6Marta Kutwin7André Chwalibog8Ewa Sawosz9Department of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandInstitute of Chemistry, Military University of Technology, 00-908 Warsaw, PolandDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandDepartment of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, DenmarkDepartment of Nanobiotechnology and Experimental Ecology, Warsaw University of Life Sciences, 02-786 Warsaw, PolandThe characteristic features of nanomaterials provide rich opportunities for a broad range of applications due to their different physicochemical properties. Nanocolloidal silver and graphenic carbon materials differ in most physicochemical characteristics, except for their nanodimensions. Since there is a growing demand for stem cell therapies for coronary disorders, examining cardiac progenitor cells (CPC) in terms of their response to nanostructure treatment seems to be a reasonable approach. Morphological studies and viability assessments were performed with CPC in vitro, treated with small concentrations of silver nanoparticles (AgNP), hierarchical nanoporous graphenic carbon (HNC) and their mixtures. A viability test confirmed the morphological assessment of CPC treated with AgNP and HNC; moreover, the action of both nanomaterials was time-dependent and dose-dependent. For AgNP, between the two of the applied concentrations lies a border between their potential beneficial effect and toxicity. For HNC, at a lower concentration, strong stimulation of cell viability was noted, whereas a higher dosage activated their differentiation. It is necessary to perform further research examining the mechanisms of the action of AgNP and especially of unexplored HNC, and their mixtures, on CPC and other cells.https://www.mdpi.com/1996-1944/13/9/2159cardiac progenitor cellshierarchical nanoporous graphenic carbonsilver nanoparticleschickennanobiotechnology |
| spellingShingle | Anna Hotowy Marta Grodzik Marlena Zielińska-Górska Natalia Chojnacka Natalia Kurantowicz Sławomir Dyjak Barbara Strojny Marta Kutwin André Chwalibog Ewa Sawosz Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells Materials cardiac progenitor cells hierarchical nanoporous graphenic carbon silver nanoparticles chicken nanobiotechnology |
| title | Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells |
| title_full | Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells |
| title_fullStr | Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells |
| title_full_unstemmed | Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells |
| title_short | Silver and Graphenic Carbon Nanostructures Differentially Influence the Morphology and Viability of Cardiac Progenitor Cells |
| title_sort | silver and graphenic carbon nanostructures differentially influence the morphology and viability of cardiac progenitor cells |
| topic | cardiac progenitor cells hierarchical nanoporous graphenic carbon silver nanoparticles chicken nanobiotechnology |
| url | https://www.mdpi.com/1996-1944/13/9/2159 |
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