Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C
Hepatitis C infection is a global health problem. Spontaneous viral clearance was observed in approximately 30% of individuals with acute infection. In the therapy using a combination of pegylated interferon-α and ribavirin, approximately 50% of chronic hepatitis C patients infected with high viremi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2011-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319307546 |
| _version_ | 1818274811609088000 |
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| author | Masaya Sugiyama Yasuhito Tanaka Makoto Nakanishi Masashi Mizokami |
| author_facet | Masaya Sugiyama Yasuhito Tanaka Makoto Nakanishi Masashi Mizokami |
| author_sort | Masaya Sugiyama |
| collection | DOAJ |
| description | Hepatitis C infection is a global health problem. Spontaneous viral clearance was observed in approximately 30% of individuals with acute infection. In the therapy using a combination of pegylated interferon-α and ribavirin, approximately 50% of chronic hepatitis C patients infected with high viremia of hepatitis C virus infection (HCV) genotype 1 reached a sustained viral response. These findings were strongly expected to reflect variations of the host genome. To reveal genetic effects against viral clearance or treatment response, four independent groups applied a genome-wide association study (GWAS) to HCV infection. These groups almost simultaneously reported a strong association of interleukin (IL)-28B polymorphisms with viral clearance or final decision of HCV therapy. The discovered single nucleotide polymorphisms (SNPs) also revealed the enigma that the viral clearance rate was dependent on ethnic type. The significant SNPs are useful for prediction prior to treatment because of the strong association with clinical outcome. In addition, the unexpected results revealed by GWAS could promote the development of a novel drug related to IL-28B. Herein, we present current understanding in regard to the relationship between host variations and clinical outcome of hepatitis C. Keywords:: hepatitis C virus, genome-wide association study, interleukin-28, interferon-λ, single nucleotide polymorphism, liver disease |
| first_indexed | 2024-12-12T22:19:47Z |
| format | Article |
| id | doaj.art-3569711a25bd4faaafaa7c681669a2ed |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-12T22:19:47Z |
| publishDate | 2011-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-3569711a25bd4faaafaa7c681669a2ed2022-12-22T00:09:57ZengElsevierJournal of Pharmacological Sciences1347-86132011-01-011153263269Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis CMasaya Sugiyama0Yasuhito Tanaka1Makoto Nakanishi2Masashi Mizokami3Department of Biochemistry and Cell Biology, 1 Kawasumi, Mizuho, Mizuho-ku, Nagoya 467-0001, Japan; The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa 272-8516, Japan; JSPS Research FellowDepartment of Virology & Liver Unit, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Mizuho-ku, Nagoya 467-0001, Japan; Corresponding author. ytanaka@med.nagoya-cu.ac.jpDepartment of Biochemistry and Cell Biology, 1 Kawasumi, Mizuho, Mizuho-ku, Nagoya 467-0001, JapanThe Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa 272-8516, JapanHepatitis C infection is a global health problem. Spontaneous viral clearance was observed in approximately 30% of individuals with acute infection. In the therapy using a combination of pegylated interferon-α and ribavirin, approximately 50% of chronic hepatitis C patients infected with high viremia of hepatitis C virus infection (HCV) genotype 1 reached a sustained viral response. These findings were strongly expected to reflect variations of the host genome. To reveal genetic effects against viral clearance or treatment response, four independent groups applied a genome-wide association study (GWAS) to HCV infection. These groups almost simultaneously reported a strong association of interleukin (IL)-28B polymorphisms with viral clearance or final decision of HCV therapy. The discovered single nucleotide polymorphisms (SNPs) also revealed the enigma that the viral clearance rate was dependent on ethnic type. The significant SNPs are useful for prediction prior to treatment because of the strong association with clinical outcome. In addition, the unexpected results revealed by GWAS could promote the development of a novel drug related to IL-28B. Herein, we present current understanding in regard to the relationship between host variations and clinical outcome of hepatitis C. Keywords:: hepatitis C virus, genome-wide association study, interleukin-28, interferon-λ, single nucleotide polymorphism, liver diseasehttp://www.sciencedirect.com/science/article/pii/S1347861319307546 |
| spellingShingle | Masaya Sugiyama Yasuhito Tanaka Makoto Nakanishi Masashi Mizokami Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C Journal of Pharmacological Sciences |
| title | Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C |
| title_full | Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C |
| title_fullStr | Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C |
| title_full_unstemmed | Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C |
| title_short | Novel Findings for the Development of Drug Therapy for Various Liver Diseases: Genetic Variation in IL-28B Is Associated With Response to the Therapy for Chronic Hepatitis C |
| title_sort | novel findings for the development of drug therapy for various liver diseases genetic variation in il 28b is associated with response to the therapy for chronic hepatitis c |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319307546 |
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