Analysis of HIV latent infection model with multiple infection stages and different drug classes
Latently infected CD[Formula: see text] T cells represent one of the major obstacles to HIV eradication even after receiving prolonged highly active anti-retroviral therapy (HAART). Long-term use of HAART causes the emergence of drug-resistant virus which is then involved in HIV transmission. In thi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Journal of Biological Dynamics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17513758.2022.2113828 |
| _version_ | 1811251987666173952 |
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| author | Areej Alshorman Nidal Al-hosainat Trachette Jackson |
| author_facet | Areej Alshorman Nidal Al-hosainat Trachette Jackson |
| author_sort | Areej Alshorman |
| collection | DOAJ |
| description | Latently infected CD[Formula: see text] T cells represent one of the major obstacles to HIV eradication even after receiving prolonged highly active anti-retroviral therapy (HAART). Long-term use of HAART causes the emergence of drug-resistant virus which is then involved in HIV transmission. In this paper, we develop mathematical HIV models with staged disease progression by incorporating entry inhibitor and latently infected cells. We find that entry inhibitor has the same effect as protease inhibitor on the model dynamics and therefore would benefit HIV patients who developed resistance to many of current anti-HIV medications. Numerical simulations illustrate the theoretical results and show that the virus and latently infected cells reach an infected steady state in the absence of treatment and are eliminated under treatment whereas the model including homeostatic proliferation of latently infected cells maintains the virus at low level during suppressive treatment. Therefore, complete cure of HIV needs complete eradication of latent reservoirs. |
| first_indexed | 2024-04-12T16:27:14Z |
| format | Article |
| id | doaj.art-3569a5484713478a8009b7ab919f4aa0 |
| institution | Directory Open Access Journal |
| issn | 1751-3758 1751-3766 |
| language | English |
| last_indexed | 2024-04-12T16:27:14Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Biological Dynamics |
| spelling | doaj.art-3569a5484713478a8009b7ab919f4aa02022-12-22T03:25:18ZengTaylor & Francis GroupJournal of Biological Dynamics1751-37581751-37662022-12-0116171373210.1080/17513758.2022.2113828Analysis of HIV latent infection model with multiple infection stages and different drug classesAreej Alshorman0Nidal Al-hosainat1Trachette Jackson2Department of Mathematics, University of Michigan, Ann Arbor, MI, USARochester Regional Health/Unity Hospital, Rochester, NY, USADepartment of Mathematics, University of Michigan, Ann Arbor, MI, USALatently infected CD[Formula: see text] T cells represent one of the major obstacles to HIV eradication even after receiving prolonged highly active anti-retroviral therapy (HAART). Long-term use of HAART causes the emergence of drug-resistant virus which is then involved in HIV transmission. In this paper, we develop mathematical HIV models with staged disease progression by incorporating entry inhibitor and latently infected cells. We find that entry inhibitor has the same effect as protease inhibitor on the model dynamics and therefore would benefit HIV patients who developed resistance to many of current anti-HIV medications. Numerical simulations illustrate the theoretical results and show that the virus and latently infected cells reach an infected steady state in the absence of treatment and are eliminated under treatment whereas the model including homeostatic proliferation of latently infected cells maintains the virus at low level during suppressive treatment. Therefore, complete cure of HIV needs complete eradication of latent reservoirs.https://www.tandfonline.com/doi/10.1080/17513758.2022.2113828HIV infection stagesstabilitylatently infected CD T cellshomeostatic proliferation of latently infected cellsentry inhibitors |
| spellingShingle | Areej Alshorman Nidal Al-hosainat Trachette Jackson Analysis of HIV latent infection model with multiple infection stages and different drug classes Journal of Biological Dynamics HIV infection stages stability latently infected CD T cells homeostatic proliferation of latently infected cells entry inhibitors |
| title | Analysis of HIV latent infection model with multiple infection stages and different drug classes |
| title_full | Analysis of HIV latent infection model with multiple infection stages and different drug classes |
| title_fullStr | Analysis of HIV latent infection model with multiple infection stages and different drug classes |
| title_full_unstemmed | Analysis of HIV latent infection model with multiple infection stages and different drug classes |
| title_short | Analysis of HIV latent infection model with multiple infection stages and different drug classes |
| title_sort | analysis of hiv latent infection model with multiple infection stages and different drug classes |
| topic | HIV infection stages stability latently infected CD T cells homeostatic proliferation of latently infected cells entry inhibitors |
| url | https://www.tandfonline.com/doi/10.1080/17513758.2022.2113828 |
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