Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates
Serostudies are needed to answer generalizable questions on disease risk. However, recruitment is usually biased by age or location. We present a nationally-representative study for dengue from 70 communities in Bangladesh. We collected data on risk factors, trapped mosquitoes and tested serum for I...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/42869 |
| _version_ | 1811252998011092992 |
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| author | Henrik Salje Kishor Kumar Paul Repon Paul Isabel Rodriguez-Barraquer Ziaur Rahman Mohammad Shafiul Alam Mahmadur Rahman Hasan Mohammad Al-Amin James Heffelfinger Emily Gurley |
| author_facet | Henrik Salje Kishor Kumar Paul Repon Paul Isabel Rodriguez-Barraquer Ziaur Rahman Mohammad Shafiul Alam Mahmadur Rahman Hasan Mohammad Al-Amin James Heffelfinger Emily Gurley |
| author_sort | Henrik Salje |
| collection | DOAJ |
| description | Serostudies are needed to answer generalizable questions on disease risk. However, recruitment is usually biased by age or location. We present a nationally-representative study for dengue from 70 communities in Bangladesh. We collected data on risk factors, trapped mosquitoes and tested serum for IgG. Out of 5866 individuals, 24% had evidence of historic infection, ranging from 3% in the north to >80% in Dhaka. Being male (aOR:1.8, [95%CI:1.5–2.0]) and recent travel (aOR:1.3, [1.1–1.8]) were linked to seropositivity. We estimate that 40 million [34.3–47.2] people have been infected nationally, with 2.4 million ([1.3–4.5]) annual infections. Had we visited only 20 communities, seropositivity estimates would have ranged from 13% to 37%, highlighting the lack of representativeness generated by small numbers of communities. Our findings have implications for both the design of serosurveys and tackling dengue in Bangladesh. |
| first_indexed | 2024-04-12T16:44:02Z |
| format | Article |
| id | doaj.art-356bd39424684b279a72cf88e0c36f07 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T16:44:02Z |
| publishDate | 2019-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-356bd39424684b279a72cf88e0c36f072022-12-22T03:24:39ZengeLife Sciences Publications LtdeLife2050-084X2019-04-01810.7554/eLife.42869Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimatesHenrik Salje0https://orcid.org/0000-0003-3626-4254Kishor Kumar Paul1https://orcid.org/0000-0002-6054-3571Repon Paul2Isabel Rodriguez-Barraquer3https://orcid.org/0000-0001-6784-1021Ziaur Rahman4Mohammad Shafiul Alam5Mahmadur Rahman6Hasan Mohammad Al-Amin7James Heffelfinger8Emily Gurley9https://orcid.org/0000-0002-8648-9403Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United StatesInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshUniversity of California, San Francisco, San Francisco, United StatesInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshInstitute of Epidemiology, Disease Control and Research (IEDCR), Dhaka, BangladeshInternational Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, BangladeshDivision of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, United StatesDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United StatesSerostudies are needed to answer generalizable questions on disease risk. However, recruitment is usually biased by age or location. We present a nationally-representative study for dengue from 70 communities in Bangladesh. We collected data on risk factors, trapped mosquitoes and tested serum for IgG. Out of 5866 individuals, 24% had evidence of historic infection, ranging from 3% in the north to >80% in Dhaka. Being male (aOR:1.8, [95%CI:1.5–2.0]) and recent travel (aOR:1.3, [1.1–1.8]) were linked to seropositivity. We estimate that 40 million [34.3–47.2] people have been infected nationally, with 2.4 million ([1.3–4.5]) annual infections. Had we visited only 20 communities, seropositivity estimates would have ranged from 13% to 37%, highlighting the lack of representativeness generated by small numbers of communities. Our findings have implications for both the design of serosurveys and tackling dengue in Bangladesh.https://elifesciences.org/articles/42869SeroprevalenceBangladeshdenguenationally-representative |
| spellingShingle | Henrik Salje Kishor Kumar Paul Repon Paul Isabel Rodriguez-Barraquer Ziaur Rahman Mohammad Shafiul Alam Mahmadur Rahman Hasan Mohammad Al-Amin James Heffelfinger Emily Gurley Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates eLife Seroprevalence Bangladesh dengue nationally-representative |
| title | Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates |
| title_full | Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates |
| title_fullStr | Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates |
| title_full_unstemmed | Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates |
| title_short | Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates |
| title_sort | nationally representative serostudy of dengue in bangladesh allows generalizable disease burden estimates |
| topic | Seroprevalence Bangladesh dengue nationally-representative |
| url | https://elifesciences.org/articles/42869 |
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