| Summary: | Drug administration through the vaginal tract is one of the oldest modalities of pharmacotherapy, and it is also one of the most explored. Since the vaginal cavity has a wide surface area, a plentiful blood supply, and a complex
network of blood arteries, it can evade hepatic first-pass metabolism and obtain high local drug concentrations.
Vaginal pills look to be a good dose form since they are simple to use, portable, and can easily deliver the
required amount of medicine. Vaginal formulations, on the other hand, are vulnerable to rapid expulsion due to
the vaginal tract’s self-cleaning action, which reduces the formulation’s efficiency. Currently, there is an increasing
amount of focus on mucoadhesive vaginal formulation research and development to fix the formulation at the
place where the medicine can be released and/or absorbed. This article examines all of the strategies used by
researchers to develop a mucoadhesive vaginal tablet that is safe, effective, and comfortable for the user.
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