The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007 fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study

The NOD2-Smoking Interaction in Crohn's Disease is likely Specific to the 1007 fs Mutation and may be Explained by Age at Diagnosis: A Meta-Analysis and Case-Only Study

Background: NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at diagnosis on NOD2-smoking interactions (Phase 2). Methods: Phase 1: MEDLINE and EMBASE were searched for studies (n...

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Bibliographic Details
Main Authors: M. Ellen Kuenzig, Jeff Yim, Stephanie Coward, Bertus Eksteen, Cynthia H. Seow, Cheryl Barnabe, Herman W. Barkema, Mark S. Silverberg, Peter L. Lakatos, Paul L. Beck, Richard Fedorak, Levinus A. Dieleman, Karen Madsen, Remo Panaccione, Subrata Ghosh, Gilaad G. Kaplan
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:EBioMedicine
Subjects:
Crohn's disease
NOD2
Cigarette smoking
Gene-environment interactions
Age
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302475

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