Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues
Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose ti...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-07-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/14/7644 |
| _version_ | 1797526913794703360 |
|---|---|
| author | Lowell Dilworth Aldeam Facey Felix Omoruyi |
| author_facet | Lowell Dilworth Aldeam Facey Felix Omoruyi |
| author_sort | Lowell Dilworth |
| collection | DOAJ |
| description | Many approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease. |
| first_indexed | 2024-03-10T09:36:06Z |
| format | Article |
| id | doaj.art-356db31b918546238304e58191ddbbea |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:06Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-356db31b918546238304e58191ddbbea2023-11-22T04:01:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214764410.3390/ijms22147644Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose TissuesLowell Dilworth0Aldeam Facey1Felix Omoruyi2Department of Pathology, Mona Campus, University of the West Indies, Kingston 7, JamaicaMona Academy of Sport, Mona Campus, University of the West Indies, Kingston 7, JamaicaDepartment of Life Sciences, Texas A&M University, Corpus Christi, TX 78412, USAMany approaches have been used in the effective management of type 2 diabetes mellitus. A recent paradigm shift has focused on the role of adipose tissues in the development and treatment of the disease. Brown adipose tissues (BAT) and white adipose tissues (WAT) are the two main types of adipose tissues with beige subsets more recently identified. They play key roles in communication and insulin sensitivity. However, WAT has been shown to contribute significantly to endocrine function. WAT produces hormones and cytokines, collectively called adipocytokines, such as leptin and adiponectin. These adipocytokines have been proven to vary in conditions, such as metabolic dysfunction, type 2 diabetes, or inflammation. The regulation of fat storage, energy metabolism, satiety, and insulin release are all features of adipose tissues. As such, they are indicators that may provide insights on the development of metabolic dysfunction or type 2 diabetes and can be considered routes for therapeutic considerations. The essential roles of adipocytokines vis-a-vis satiety, appetite, regulation of fat storage and energy, glucose tolerance, and insulin release, solidifies adipose tissue role in the development and pathogenesis of diabetes mellitus and the complications associated with the disease.https://www.mdpi.com/1422-0067/22/14/7644diabetes mellitusadiposeinsulin resistance |
| spellingShingle | Lowell Dilworth Aldeam Facey Felix Omoruyi Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues International Journal of Molecular Sciences diabetes mellitus adipose insulin resistance |
| title | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
| title_full | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
| title_fullStr | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
| title_full_unstemmed | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
| title_short | Diabetes Mellitus and Its Metabolic Complications: The Role of Adipose Tissues |
| title_sort | diabetes mellitus and its metabolic complications the role of adipose tissues |
| topic | diabetes mellitus adipose insulin resistance |
| url | https://www.mdpi.com/1422-0067/22/14/7644 |
| work_keys_str_mv | AT lowelldilworth diabetesmellitusanditsmetaboliccomplicationstheroleofadiposetissues AT aldeamfacey diabetesmellitusanditsmetaboliccomplicationstheroleofadiposetissues AT felixomoruyi diabetesmellitusanditsmetaboliccomplicationstheroleofadiposetissues |