Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging
Transdermal drug delivery (TDD) is less invasive and avoids first-pass metabolism, making it an attractive method for treating various diseases such as diabetes and hypertension. However, current methods for evaluating TDD systems lack in vivo descriptions of drug distribution in the skin. In this s...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597923000836 |
| _version_ | 1797731006088740864 |
|---|---|
| author | Yang Xie Huayi Wu Ziyan Chen Qi Sun Xiangdong Liu Jinsheng Jiang Bo Wang Zeyu Chen |
| author_facet | Yang Xie Huayi Wu Ziyan Chen Qi Sun Xiangdong Liu Jinsheng Jiang Bo Wang Zeyu Chen |
| author_sort | Yang Xie |
| collection | DOAJ |
| description | Transdermal drug delivery (TDD) is less invasive and avoids first-pass metabolism, making it an attractive method for treating various diseases such as diabetes and hypertension. However, current methods for evaluating TDD systems lack in vivo descriptions of drug distribution in the skin. In this study, we demonstrate the capability of the Transient Triplet Differential (TTD) method, a non-invasive and background-free photoacoustic imaging technique, for accurately mapping drug distribution and evaluating different TDD systems. Our findings show that the TTD method can provide high sensitivity and specificity for targeted drug extraction and visualize 3D drug distribution in the skin. Furthermore, in vivo experiments confirmed the potential of the TTD method in evaluating the clinical performance of TDD. It’s predictable that the TTD method can be a reliable and non-invasive approach for evaluating TDD systems and offer valuable insights into TDD research and development. |
| first_indexed | 2024-03-12T11:53:16Z |
| format | Article |
| id | doaj.art-356efca4fcf74f8ca23082e9be33c9fc |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-03-12T11:53:16Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-356efca4fcf74f8ca23082e9be33c9fc2023-08-31T05:02:44ZengElsevierPhotoacoustics2213-59792023-08-0132100530Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imagingYang Xie0Huayi Wu1Ziyan Chen2Qi Sun3Xiangdong Liu4Jinsheng Jiang5Bo Wang6Zeyu Chen7School of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, ChinaDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China; Corresponding authors.School of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China; Corresponding authors.Transdermal drug delivery (TDD) is less invasive and avoids first-pass metabolism, making it an attractive method for treating various diseases such as diabetes and hypertension. However, current methods for evaluating TDD systems lack in vivo descriptions of drug distribution in the skin. In this study, we demonstrate the capability of the Transient Triplet Differential (TTD) method, a non-invasive and background-free photoacoustic imaging technique, for accurately mapping drug distribution and evaluating different TDD systems. Our findings show that the TTD method can provide high sensitivity and specificity for targeted drug extraction and visualize 3D drug distribution in the skin. Furthermore, in vivo experiments confirmed the potential of the TTD method in evaluating the clinical performance of TDD. It’s predictable that the TTD method can be a reliable and non-invasive approach for evaluating TDD systems and offer valuable insights into TDD research and development.http://www.sciencedirect.com/science/article/pii/S2213597923000836Evaluation of transdermal drug deliveryTransient triplet differential (TTD) methodPhotoacoustic imaging3D imagingNon-invasiveBackground-free |
| spellingShingle | Yang Xie Huayi Wu Ziyan Chen Qi Sun Xiangdong Liu Jinsheng Jiang Bo Wang Zeyu Chen Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging Photoacoustics Evaluation of transdermal drug delivery Transient triplet differential (TTD) method Photoacoustic imaging 3D imaging Non-invasive Background-free |
| title | Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging |
| title_full | Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging |
| title_fullStr | Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging |
| title_full_unstemmed | Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging |
| title_short | Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging |
| title_sort | non invasive evaluation of transdermal drug delivery using 3 d transient triplet differential ttd photoacoustic imaging |
| topic | Evaluation of transdermal drug delivery Transient triplet differential (TTD) method Photoacoustic imaging 3D imaging Non-invasive Background-free |
| url | http://www.sciencedirect.com/science/article/pii/S2213597923000836 |
| work_keys_str_mv | AT yangxie noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT huayiwu noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT ziyanchen noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT qisun noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT xiangdongliu noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT jinshengjiang noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT bowang noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging AT zeyuchen noninvasiveevaluationoftransdermaldrugdeliveryusing3dtransienttripletdifferentialttdphotoacousticimaging |