Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder
There is growing evidence that inflammation plays a role in major depressive disorder (MDD). As the main role of regulatory T cells (Tregs) is to control inflammation, this might denote a Treg insufficiency in MDD. However, neither a qualitative nor a quantitative defect of Tregs has been ascertaine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2018.00167/full |
| _version_ | 1818271747116367872 |
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| author | Pierre Ellul Encarnita Mariotti-Ferrandiz Marion Leboyer Marion Leboyer Marion Leboyer David Klatzmann |
| author_facet | Pierre Ellul Encarnita Mariotti-Ferrandiz Marion Leboyer Marion Leboyer Marion Leboyer David Klatzmann |
| author_sort | Pierre Ellul |
| collection | DOAJ |
| description | There is growing evidence that inflammation plays a role in major depressive disorder (MDD). As the main role of regulatory T cells (Tregs) is to control inflammation, this might denote a Treg insufficiency in MDD. However, neither a qualitative nor a quantitative defect of Tregs has been ascertained and no causality direction between inflammation and depression has been established. Here, after reviewing the evidence supporting a relation between Treg insufficiency and MDD, we conclude that a novel therapeutic approach based on Treg stimulation could be valuable in at least the subset of patients with inflammatory MDD. Low-dose interleukin-2 appears to be a good candidate as it is not only a safe stimulator of Tregs in humans but also an inhibitor of pro-inflammatory Th17 lymphocytes. Here, we discuss that a thorough immune investigation as well as immunotherapy will be heuristic for deciphering the pathophysiology of MDD. |
| first_indexed | 2024-12-12T21:31:05Z |
| format | Article |
| id | doaj.art-357165af2d97487680bf3783ef802914 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T21:31:05Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-357165af2d97487680bf3783ef8029142022-12-22T00:11:19ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-03-01910.3389/fneur.2018.00167343680Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive DisorderPierre Ellul0Encarnita Mariotti-Ferrandiz1Marion Leboyer2Marion Leboyer3Marion Leboyer4David Klatzmann5Sorbonne Université, Assistance Publique - Hôpitaux de Paris (AP-HP), Robert Debré Hospital, Department of Child and Adolescent Psychiatry, Paris, FranceSorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, FranceTeam 15, INSERM U955 Institut Mondor de Recherche Biomédicale (IMRB), Créteil, FranceFaculté de Médecine, Université Paris-Est Créteil Val de Marne (UPEC), DHU PePSY, Pôle de Psychiatrie et d’addictologie, Hôpitaux Universitaires Mondor, Assistance Publique - Hôpitaux de Paris (AP-HP), Créteil, FranceFondation FondaMental, Créteil, FranceSorbonne Université, INSERM, Immunology-Immunopathology-Immunotherapy (i3), AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B), Paris, FranceThere is growing evidence that inflammation plays a role in major depressive disorder (MDD). As the main role of regulatory T cells (Tregs) is to control inflammation, this might denote a Treg insufficiency in MDD. However, neither a qualitative nor a quantitative defect of Tregs has been ascertained and no causality direction between inflammation and depression has been established. Here, after reviewing the evidence supporting a relation between Treg insufficiency and MDD, we conclude that a novel therapeutic approach based on Treg stimulation could be valuable in at least the subset of patients with inflammatory MDD. Low-dose interleukin-2 appears to be a good candidate as it is not only a safe stimulator of Tregs in humans but also an inhibitor of pro-inflammatory Th17 lymphocytes. Here, we discuss that a thorough immune investigation as well as immunotherapy will be heuristic for deciphering the pathophysiology of MDD.http://journal.frontiersin.org/article/10.3389/fneur.2018.00167/fullregulatory T cellmajor depressive disordersinflammationimmunotherapylow-dose interleukin-2 |
| spellingShingle | Pierre Ellul Encarnita Mariotti-Ferrandiz Marion Leboyer Marion Leboyer Marion Leboyer David Klatzmann Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder Frontiers in Neurology regulatory T cell major depressive disorders inflammation immunotherapy low-dose interleukin-2 |
| title | Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder |
| title_full | Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder |
| title_fullStr | Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder |
| title_full_unstemmed | Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder |
| title_short | Regulatory T Cells As Supporters of Psychoimmune Resilience: Toward Immunotherapy of Major Depressive Disorder |
| title_sort | regulatory t cells as supporters of psychoimmune resilience toward immunotherapy of major depressive disorder |
| topic | regulatory T cell major depressive disorders inflammation immunotherapy low-dose interleukin-2 |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2018.00167/full |
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