Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement

Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement

Warfarin has been widely used as an oral anticoagulant agent. In past, efforts have been done to study the contribution of genetic variation on warfarin dose requirements. The possible therapeutic dose determination of warfarin is very challenging, i.e., extremely low dose leading to unusable antith...

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Bibliographic Details
Main Authors: Huma Shafique, Naeem Mahmood Ashraf, Amir Rashid, Asifa Majeed, Tayyaba Afsar, Ann K. Daly, Ali Almajwal, Nawaf W. Alruwaili, Azmat Ullah Khan, Suhail Razak
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
VKORC1
CYP2C9
pleiotropy
IL-6
TNF-α
COX-2
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.895169/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.895169/full

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