Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period
Objective: CRP was the most commonly used marker of inflammation in renal transplant recipients in chronic renal disease, and renal functions were monitored with creatinine levels. In this study, we recorded the early course of B2 microglobulin and pentraxin levels as inflammatory markers in renal...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ali İhsan Taşçı
2020-06-01
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| Series: | Yeni Üroloji Dergisi |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1110046 |
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| author | Yenice, Mustafa Gürkan Karadağ, Serdar Sungur, Ubeyd Akbay, Fatih Gökhan Şeker, Kamil Gökhan Güler, A.Faysal Kural, Alev Apaydın, Süheyla Taşçı, Ali İhsan |
| author_facet | Yenice, Mustafa Gürkan Karadağ, Serdar Sungur, Ubeyd Akbay, Fatih Gökhan Şeker, Kamil Gökhan Güler, A.Faysal Kural, Alev Apaydın, Süheyla Taşçı, Ali İhsan |
| author_sort | Yenice, Mustafa Gürkan |
| collection | DOAJ |
| description | Objective: CRP was the most commonly used
marker of inflammation in renal transplant recipients in chronic renal disease, and renal functions were monitored with creatinine levels. In this
study, we recorded the early course of B2 microglobulin and pentraxin levels as inflammatory markers in renal transplant patients and aimed to determine its usefulness as markers of inflammation.
Materials and Methods: This is a prospective
observation study of 23 adult patients who underwent renal transplantation from living donors
between January and June 2017. Demographic
characteristics, blood samples, biochemical parameters and inflammation markers were studied on
the first day, 3rd day, 7th day and 30th day after
transplantation.
Results: 18 (78%) of the 23 patients included
in our study were in the pre-transplant dialysis
program and 5 (22%) received preemptive dialysis.
There were significant decreases in B2 microglobulin levels on the first postoperative day on the
3rd day and 7th day (p <0.05), but no significant
difference was found between the 1st week and the
first month (p> 0.05). Creatinine levels decreased
significantly on the third day compared to the
first day. There was a significant positive correlation between B2 microglobulin and creatinine at
postoperative day 0, day 3, day 7 and month 1 (p
<0.05). Pentraxine and CRP levels increased significantly on the third day compared to the first day,
then decreased significantly on the 7th day and
the first month. (P <0.05) However, there was no
significant correlation between pentraxin changes
and CRP changes.
Conclusion: Early detection of inflammation in renal transplant
recipients is important for the risk of graft rejection. B2 microglobulin and pentraxin levels may be used as new markers for graft rejection and renal function evaluation, but randomized controlled trials
with larger patient numbers are needed. |
| first_indexed | 2024-04-10T11:20:57Z |
| format | Article |
| id | doaj.art-35751058074640b0909756096bf3b558 |
| institution | Directory Open Access Journal |
| issn | 1305-2489 2687-1955 |
| language | English |
| last_indexed | 2024-04-10T11:20:57Z |
| publishDate | 2020-06-01 |
| publisher | Ali İhsan Taşçı |
| record_format | Article |
| series | Yeni Üroloji Dergisi |
| spelling | doaj.art-35751058074640b0909756096bf3b5582023-02-15T16:18:37ZengAli İhsan TaşçıYeni Üroloji Dergisi1305-24892687-19552020-06-0115212112610.33719/yud.643442Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation PeriodYenice, Mustafa Gürkan 0https://orcid.org/0000-0002-5813-3565Karadağ, Serdar 1https://orcid.org/0000-0002-1420-4536Sungur, Ubeyd2https://orcid.org/0000-0002-8910-9859Akbay, Fatih Gökhan 3https://orcid.org/0000-0002-4263-1391Şeker, Kamil Gökhan 4https://orcid.org/0000-0003-4449-9037Güler, A.Faysal5https://orcid.org/0000-0003-0320-7843Kural, Alev6https://orcid.org/0000-0003-1459-4316Apaydın, Süheyla 7https://orcid.org/0000-0001-6224-405XTaşçı, Ali İhsan8https://orcid.org/0000-0002-6943-6676Sağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Üroloji Anabilim Dalı, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Üroloji Anabilim Dalı, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Üroloji Anabilim Dalı, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İstanbul, Türkiye Muş Devlet Hastanesi, MuşSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Üroloji Anabilim Dalı, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Biyokimya, İstanbulSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İstanbul, TürkiyeSağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Üroloji Anabilim Dalı, İstanbul, TürkiyeObjective: CRP was the most commonly used marker of inflammation in renal transplant recipients in chronic renal disease, and renal functions were monitored with creatinine levels. In this study, we recorded the early course of B2 microglobulin and pentraxin levels as inflammatory markers in renal transplant patients and aimed to determine its usefulness as markers of inflammation. Materials and Methods: This is a prospective observation study of 23 adult patients who underwent renal transplantation from living donors between January and June 2017. Demographic characteristics, blood samples, biochemical parameters and inflammation markers were studied on the first day, 3rd day, 7th day and 30th day after transplantation. Results: 18 (78%) of the 23 patients included in our study were in the pre-transplant dialysis program and 5 (22%) received preemptive dialysis. There were significant decreases in B2 microglobulin levels on the first postoperative day on the 3rd day and 7th day (p <0.05), but no significant difference was found between the 1st week and the first month (p> 0.05). Creatinine levels decreased significantly on the third day compared to the first day. There was a significant positive correlation between B2 microglobulin and creatinine at postoperative day 0, day 3, day 7 and month 1 (p <0.05). Pentraxine and CRP levels increased significantly on the third day compared to the first day, then decreased significantly on the 7th day and the first month. (P <0.05) However, there was no significant correlation between pentraxin changes and CRP changes. Conclusion: Early detection of inflammation in renal transplant recipients is important for the risk of graft rejection. B2 microglobulin and pentraxin levels may be used as new markers for graft rejection and renal function evaluation, but randomized controlled trials with larger patient numbers are needed.https://dergipark.org.tr/tr/download/article-file/1110046b2-microglobulininflammationpentraxintransplantation |
| spellingShingle | Yenice, Mustafa Gürkan Karadağ, Serdar Sungur, Ubeyd Akbay, Fatih Gökhan Şeker, Kamil Gökhan Güler, A.Faysal Kural, Alev Apaydın, Süheyla Taşçı, Ali İhsan Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period Yeni Üroloji Dergisi b2-microglobulin inflammation pentraxin transplantation |
| title | Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period |
| title_full | Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period |
| title_fullStr | Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period |
| title_full_unstemmed | Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period |
| title_short | Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period |
| title_sort | use of b 2 microglobulin and pentraxin as an inflammatory marker in the early post renal transplantation period |
| topic | b2-microglobulin inflammation pentraxin transplantation |
| url | https://dergipark.org.tr/tr/download/article-file/1110046 |
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