Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV
The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adol...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800006&lng=en&tlng=en |
| _version_ | 1827831657357377536 |
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| author | Daisy Maria Machado Maria Cristina Fink Cláudio Sérgio Pannuti Regina Célia de Menezes Succi Alessandra Aparecida Machado Fabiana Bononi do Carmo Aída de Fátima Barbosa Gouvêa Paulo Roberto Urbano Suenia Vasconcelos Beltrão Isabel Cristina Lopes dos Santos Clarisse Martins Machado |
| author_facet | Daisy Maria Machado Maria Cristina Fink Cláudio Sérgio Pannuti Regina Célia de Menezes Succi Alessandra Aparecida Machado Fabiana Bononi do Carmo Aída de Fátima Barbosa Gouvêa Paulo Roberto Urbano Suenia Vasconcelos Beltrão Isabel Cristina Lopes dos Santos Clarisse Martins Machado |
| author_sort | Daisy Maria Machado |
| collection | DOAJ |
| description | The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance. |
| first_indexed | 2024-03-12T04:57:31Z |
| format | Article |
| id | doaj.art-357534605db742eb8d7617f521341163 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:57:31Z |
| publishDate | 2011-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-357534605db742eb8d7617f5213411632023-09-03T09:14:39ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-12-01106893193510.1590/S0074-02762011000800006S0074-02762011000800006Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIVDaisy Maria Machado0Maria Cristina Fink1Cláudio Sérgio Pannuti2Regina Célia de Menezes Succi3Alessandra Aparecida Machado4Fabiana Bononi do Carmo5Aída de Fátima Barbosa Gouvêa6Paulo Roberto Urbano7Suenia Vasconcelos Beltrão8Isabel Cristina Lopes dos Santos9Clarisse Martins Machado10Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade Federal de São PauloUniversidade de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloThe aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800006&lng=en&tlng=enHIV-1childadolescentJC virusBK virusurine |
| spellingShingle | Daisy Maria Machado Maria Cristina Fink Cláudio Sérgio Pannuti Regina Célia de Menezes Succi Alessandra Aparecida Machado Fabiana Bononi do Carmo Aída de Fátima Barbosa Gouvêa Paulo Roberto Urbano Suenia Vasconcelos Beltrão Isabel Cristina Lopes dos Santos Clarisse Martins Machado Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV Memorias do Instituto Oswaldo Cruz HIV-1 child adolescent JC virus BK virus urine |
| title | Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
| title_full | Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
| title_fullStr | Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
| title_full_unstemmed | Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
| title_short | Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV |
| title_sort | human polyomaviruses jc and bk in the urine of brazilian children and adolescents vertically infected by hiv |
| topic | HIV-1 child adolescent JC virus BK virus urine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800006&lng=en&tlng=en |
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