The cut-off values of vitamin D deficiency in early infancy
Background: Several cut-off points for 25-hydroxyvitamin D (25(OH)D) levels have been proposed to determine vitamin D deficiency or insufficiency. However, the level for 25(OH)D deficiency in early infancy remains unclear. The serum 25(OH)D value at which parathyroid hormone level plateaus, called t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957222000523 |
| _version_ | 1818532903504576512 |
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| author | Kazushige Ikeda Kaori Hara-Isono Keigo Takahashi Takeshi Arimitsu Yasunori Sato |
| author_facet | Kazushige Ikeda Kaori Hara-Isono Keigo Takahashi Takeshi Arimitsu Yasunori Sato |
| author_sort | Kazushige Ikeda |
| collection | DOAJ |
| description | Background: Several cut-off points for 25-hydroxyvitamin D (25(OH)D) levels have been proposed to determine vitamin D deficiency or insufficiency. However, the level for 25(OH)D deficiency in early infancy remains unclear. The serum 25(OH)D value at which parathyroid hormone level plateaus, called the “inflection point,” is considered the most appropriate criterion for defining an adequate vitamin D status. Methods: This was a single-center retrospective study involving 305 1-month-old and 252 2-month-old Japanese infants. Nonlinear segmented regression analysis was performed based on the correlation between 25(OH)D and parathyroid hormone levels to determine vitamin D deficiency cut-off points. Results: Inflection points were 7.90 ng/mL for 1-month-old (95% confidence interval, 6.31–9.49) and 6.74 ng/mL for 2-month-old (95% confidence interval, 5.80–7.68) Japanese infants, which were lower than previously reported. Cut-off values were also lower in the high-body mass index (BMI) group than in the low-BMI group for both 1-month and 2-month-old infants. Conclusion: These results imply the need for nutritional rickets prevention via policy recommendations in most full-term newborns in Japan. Although validation studies are required, these results can still be used to guide vitamin D insufficiency treatment options in early infancy. |
| first_indexed | 2024-12-11T17:51:37Z |
| format | Article |
| id | doaj.art-357584a1b0b9445781d3cc266cd5649f |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-11T17:51:37Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-357584a1b0b9445781d3cc266cd5649f2022-12-22T00:56:11ZengElsevierPediatrics and Neonatology1875-95722022-07-01634361367The cut-off values of vitamin D deficiency in early infancyKazushige Ikeda0Kaori Hara-Isono1Keigo Takahashi2Takeshi Arimitsu3Yasunori Sato4Division of Neonatology, Department of Pediatrics, Saitama City Hospital, Saitama, Japan; Corresponding author. Division of Neonatology, Department of Pediatrics, Saitama City Hospital, 2460 Mimuro, Midori-ku, Saitama City, Saitama, Japan.Department of Pediatrics, Keio University School of Medicine, Tokyo, JapanDivision of Neonatology, Department of Pediatrics, Saitama City Hospital, Saitama, JapanDepartment of Pediatrics, Keio University School of Medicine, Tokyo, JapanDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, JapanBackground: Several cut-off points for 25-hydroxyvitamin D (25(OH)D) levels have been proposed to determine vitamin D deficiency or insufficiency. However, the level for 25(OH)D deficiency in early infancy remains unclear. The serum 25(OH)D value at which parathyroid hormone level plateaus, called the “inflection point,” is considered the most appropriate criterion for defining an adequate vitamin D status. Methods: This was a single-center retrospective study involving 305 1-month-old and 252 2-month-old Japanese infants. Nonlinear segmented regression analysis was performed based on the correlation between 25(OH)D and parathyroid hormone levels to determine vitamin D deficiency cut-off points. Results: Inflection points were 7.90 ng/mL for 1-month-old (95% confidence interval, 6.31–9.49) and 6.74 ng/mL for 2-month-old (95% confidence interval, 5.80–7.68) Japanese infants, which were lower than previously reported. Cut-off values were also lower in the high-body mass index (BMI) group than in the low-BMI group for both 1-month and 2-month-old infants. Conclusion: These results imply the need for nutritional rickets prevention via policy recommendations in most full-term newborns in Japan. Although validation studies are required, these results can still be used to guide vitamin D insufficiency treatment options in early infancy.http://www.sciencedirect.com/science/article/pii/S187595722200052325-hydroxyvitaminDbroken line regressioncut-off valueinflection pointvitamin D deficiency |
| spellingShingle | Kazushige Ikeda Kaori Hara-Isono Keigo Takahashi Takeshi Arimitsu Yasunori Sato The cut-off values of vitamin D deficiency in early infancy Pediatrics and Neonatology 25-hydroxyvitaminD broken line regression cut-off value inflection point vitamin D deficiency |
| title | The cut-off values of vitamin D deficiency in early infancy |
| title_full | The cut-off values of vitamin D deficiency in early infancy |
| title_fullStr | The cut-off values of vitamin D deficiency in early infancy |
| title_full_unstemmed | The cut-off values of vitamin D deficiency in early infancy |
| title_short | The cut-off values of vitamin D deficiency in early infancy |
| title_sort | cut off values of vitamin d deficiency in early infancy |
| topic | 25-hydroxyvitaminD broken line regression cut-off value inflection point vitamin D deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S1875957222000523 |
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