Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities
To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00103/full |
| _version_ | 1811218761154297856 |
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| author | Florencia Paula Madorsky Rowdo María Laura Lacreu José eMordoh |
| author_facet | Florencia Paula Madorsky Rowdo María Laura Lacreu José eMordoh |
| author_sort | Florencia Paula Madorsky Rowdo |
| collection | DOAJ |
| description | To endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as Cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer. |
| first_indexed | 2024-04-12T07:13:35Z |
| format | Article |
| id | doaj.art-35767b2bd2eb44a18a3d16193282484e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T07:13:35Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-35767b2bd2eb44a18a3d16193282484e2022-12-22T03:42:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-05-01310.3389/fimmu.2012.0010324468Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realitiesFlorencia Paula Madorsky Rowdo0María Laura Lacreu1José eMordoh2Fundación Instituto LeloirFundación Instituto LeloirFundación Instituto LeloirTo endow the immune system with the capacity to fight cancer has always attracted attention, although the clinical results obtained have been until recently disappointing. Cutaneous melanoma is a highly immunogenic tumor; therefore most of the attempts to produce cancer vaccines have been addressed to this disease. New advances in the comprehension of the mechanisms of antigen presentation by dendritic cells, in the immune responses triggered by adjuvants, as well as the understanding of the role of immunosuppressor molecules such as Cytotoxic T-lymphocyte antigen-4 (CTLA-4), which led to the recent approval of the anti-CTLA-4 monoclonal antibody ipilimumab, have opened new hopes about the installment of immunotherapy as a new modality to treat cancer.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00103/fullCancer VaccinesImmunotherapyMelanomaCTLA-4 |
| spellingShingle | Florencia Paula Madorsky Rowdo María Laura Lacreu José eMordoh Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities Frontiers in Immunology Cancer Vaccines Immunotherapy Melanoma CTLA-4 |
| title | Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
| title_full | Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
| title_fullStr | Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
| title_full_unstemmed | Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
| title_short | Melanoma vaccines and modulation of the immune system in the clinical setting: building from new realities |
| title_sort | melanoma vaccines and modulation of the immune system in the clinical setting building from new realities |
| topic | Cancer Vaccines Immunotherapy Melanoma CTLA-4 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00103/full |
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