Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study
AbstractAccumulating evidence has highlighted the importance of immune cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the understanding of the causal association between immunity and COPD remains incomplete due to the existence of confounding variables. In this s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | COPD |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2024.2327352 |
| _version_ | 1797222431967936512 |
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| author | Xinru Xiao Ziqi Ding Yujia Shi Qian Zhang |
| author_facet | Xinru Xiao Ziqi Ding Yujia Shi Qian Zhang |
| author_sort | Xinru Xiao |
| collection | DOAJ |
| description | AbstractAccumulating evidence has highlighted the importance of immune cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the understanding of the causal association between immunity and COPD remains incomplete due to the existence of confounding variables. In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing the genome-wide association study database, to investigate the causal association between 731 immune-cell signatures and the susceptibility to COPD from a host genetics perspective. To validate the consistency of our findings, we utilized MR analysis results of lung function data to assess directional concordance. Furthermore, we employed MR-Egger intercept tests, Cochrane’s Q test, MR-PRESSO global test, and "leave-one-out" sensitivity analyses to evaluate the presence of horizontal pleiotropy, heterogeneity, and stability, respectively. Inverse variance weighting results showed that seven immune phenotypes were associated with the risk of COPD. Analyses of heterogeneity and pleiotropy analysis confirmed the reliability of MR results. These results highlight the interactions between the immune system and the lungs. Further investigations into their mechanisms are necessary and will contribute to inform targeted prevention strategies for COPD. |
| first_indexed | 2024-04-24T13:21:14Z |
| format | Article |
| id | doaj.art-3577a729d5cf472c8b3fd0ef994b947e |
| institution | Directory Open Access Journal |
| issn | 1541-2555 1541-2563 |
| language | English |
| last_indexed | 2024-04-24T13:21:14Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj.art-3577a729d5cf472c8b3fd0ef994b947e2024-04-04T13:23:41ZengTaylor & Francis GroupCOPD1541-25551541-25632024-12-0121110.1080/15412555.2024.2327352Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization StudyXinru Xiao0Ziqi Ding1Yujia Shi2Qian Zhang3Department of Respiratory and Critical Care Medicine, The Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University, Changzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University, Changzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University, Changzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University, Changzhou, ChinaAbstractAccumulating evidence has highlighted the importance of immune cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the understanding of the causal association between immunity and COPD remains incomplete due to the existence of confounding variables. In this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing the genome-wide association study database, to investigate the causal association between 731 immune-cell signatures and the susceptibility to COPD from a host genetics perspective. To validate the consistency of our findings, we utilized MR analysis results of lung function data to assess directional concordance. Furthermore, we employed MR-Egger intercept tests, Cochrane’s Q test, MR-PRESSO global test, and "leave-one-out" sensitivity analyses to evaluate the presence of horizontal pleiotropy, heterogeneity, and stability, respectively. Inverse variance weighting results showed that seven immune phenotypes were associated with the risk of COPD. Analyses of heterogeneity and pleiotropy analysis confirmed the reliability of MR results. These results highlight the interactions between the immune system and the lungs. Further investigations into their mechanisms are necessary and will contribute to inform targeted prevention strategies for COPD.https://www.tandfonline.com/doi/10.1080/15412555.2024.2327352Chronic obstructive pulmonary diseaseimmune cellsimmunophenotypesMendelian randomization |
| spellingShingle | Xinru Xiao Ziqi Ding Yujia Shi Qian Zhang Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study COPD Chronic obstructive pulmonary disease immune cells immunophenotypes Mendelian randomization |
| title | Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study |
| title_full | Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study |
| title_fullStr | Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study |
| title_full_unstemmed | Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study |
| title_short | Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study |
| title_sort | causal role of immune cells in chronic obstructive pulmonary disease a two sample mendelian randomization study |
| topic | Chronic obstructive pulmonary disease immune cells immunophenotypes Mendelian randomization |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2024.2327352 |
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