Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population
Purpose: To examine the association between choroidal thickness and myopic maculopathy in a general Japanese population. Design: Population-based cross-sectional study. Participants: A total of 2841 residents of a Japanese community aged ≥ 40 years, who consented to participate and had available dat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Ophthalmology Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914523000829 |
| _version_ | 1797377748089438208 |
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| author | Emi Ueda, MD, PhD Miho Yasuda, MD, PhD Kohta Fujiwara, MD, PhD Sawako Hashimoto, MD, PhD Takanori Honda, PhD Shun Nakamura, MD Jun Hata, MD, PhD Toshiharu Ninomiya, MD, PhD Koh-Hei Sonoda, MD, PhD |
| author_facet | Emi Ueda, MD, PhD Miho Yasuda, MD, PhD Kohta Fujiwara, MD, PhD Sawako Hashimoto, MD, PhD Takanori Honda, PhD Shun Nakamura, MD Jun Hata, MD, PhD Toshiharu Ninomiya, MD, PhD Koh-Hei Sonoda, MD, PhD |
| author_sort | Emi Ueda, MD, PhD |
| collection | DOAJ |
| description | Purpose: To examine the association between choroidal thickness and myopic maculopathy in a general Japanese population. Design: Population-based cross-sectional study. Participants: A total of 2841 residents of a Japanese community aged ≥ 40 years, who consented to participate and had available data of choroidal thickness and fundus photographs, were enrolled in this study. Methods: The choroidal thickness was measured by swept-source OCT. Participants were divided into quartiles of choroidal thickness. Myopic maculopathy was defined according to the classification system of the Meta-analysis of Pathologic Myopia Study Group. Main outcome measures were odds ratios (ORs) of choroidal thickness for prevalent myopic maculopathy. The ORs and 95% confidence intervals (CIs) were estimated using a logistic regression model. Main Outcome Measures: Prevalent myopic maculopathy. Results: Eighty-one participants had myopic maculopathy (45 diffuse chorioretinal atrophy, 31 patchy chorioretinal atrophy, and 5 macular atrophy). Individuals in the lowest quartile of choroidal thickness had a significantly greater OR for the presence of myopic maculopathy than those in the highest quartile of choroidal thickness (OR: 4.78 [95% CI: 1.78–16.72]) after adjusting for confounders, including axial length. The sensitivity analysis among the 1176 myopic individuals with axial length of ≥ 24.0 mm also showed that thinner choroidal thickness was significantly associated with prevalent myopic maculopathy. Conclusions: The present study demonstrated the significant inverse association between choroidal thickness and the likelihood of myopic maculopathy, suggesting that the measurement of choroidal thickness in addition to axial length would be useful for assessing the risk of myopic maculopathy and elucidating its pathogenesis. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. |
| first_indexed | 2024-03-08T19:57:55Z |
| format | Article |
| id | doaj.art-35798ffd93944a1f815cec71a49ffc3d |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-03-08T19:57:55Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-35798ffd93944a1f815cec71a49ffc3d2023-12-24T04:47:06ZengElsevierOphthalmology Science2666-91452023-12-0134100350Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese PopulationEmi Ueda, MD, PhD0Miho Yasuda, MD, PhD1Kohta Fujiwara, MD, PhD2Sawako Hashimoto, MD, PhD3Takanori Honda, PhD4Shun Nakamura, MD5Jun Hata, MD, PhD6Toshiharu Ninomiya, MD, PhD7Koh-Hei Sonoda, MD, PhD8Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Correspondence: Miho Yasuda, MD, PhD, Department of Ophthalmology, Graduate School of Medical, Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanPurpose: To examine the association between choroidal thickness and myopic maculopathy in a general Japanese population. Design: Population-based cross-sectional study. Participants: A total of 2841 residents of a Japanese community aged ≥ 40 years, who consented to participate and had available data of choroidal thickness and fundus photographs, were enrolled in this study. Methods: The choroidal thickness was measured by swept-source OCT. Participants were divided into quartiles of choroidal thickness. Myopic maculopathy was defined according to the classification system of the Meta-analysis of Pathologic Myopia Study Group. Main outcome measures were odds ratios (ORs) of choroidal thickness for prevalent myopic maculopathy. The ORs and 95% confidence intervals (CIs) were estimated using a logistic regression model. Main Outcome Measures: Prevalent myopic maculopathy. Results: Eighty-one participants had myopic maculopathy (45 diffuse chorioretinal atrophy, 31 patchy chorioretinal atrophy, and 5 macular atrophy). Individuals in the lowest quartile of choroidal thickness had a significantly greater OR for the presence of myopic maculopathy than those in the highest quartile of choroidal thickness (OR: 4.78 [95% CI: 1.78–16.72]) after adjusting for confounders, including axial length. The sensitivity analysis among the 1176 myopic individuals with axial length of ≥ 24.0 mm also showed that thinner choroidal thickness was significantly associated with prevalent myopic maculopathy. Conclusions: The present study demonstrated the significant inverse association between choroidal thickness and the likelihood of myopic maculopathy, suggesting that the measurement of choroidal thickness in addition to axial length would be useful for assessing the risk of myopic maculopathy and elucidating its pathogenesis. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.http://www.sciencedirect.com/science/article/pii/S2666914523000829Choroidal thicknessMyopiaMyopic maculopathyPopulation-based studySS-OCT |
| spellingShingle | Emi Ueda, MD, PhD Miho Yasuda, MD, PhD Kohta Fujiwara, MD, PhD Sawako Hashimoto, MD, PhD Takanori Honda, PhD Shun Nakamura, MD Jun Hata, MD, PhD Toshiharu Ninomiya, MD, PhD Koh-Hei Sonoda, MD, PhD Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population Ophthalmology Science Choroidal thickness Myopia Myopic maculopathy Population-based study SS-OCT |
| title | Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population |
| title_full | Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population |
| title_fullStr | Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population |
| title_full_unstemmed | Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population |
| title_short | Association Between Choroidal Thickness and Myopic Maculopathy in a Japanese Population |
| title_sort | association between choroidal thickness and myopic maculopathy in a japanese population |
| topic | Choroidal thickness Myopia Myopic maculopathy Population-based study SS-OCT |
| url | http://www.sciencedirect.com/science/article/pii/S2666914523000829 |
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