Human Guanylate-Binding Protein 1 Positively Regulates Japanese Encephalitis Virus Replication in an Interferon Gamma Primed Environment

Human Guanylate-Binding Protein 1 Positively Regulates Japanese Encephalitis Virus Replication in an Interferon Gamma Primed Environment

RNA virus infection triggers interferon (IFN) receptor signaling, leading to the activation of hundreds of interferon-stimulated genes (ISGs). Guanylate-binding proteins (GBPs) belong to one such IFN inducible subfamily of guanosine triphosphatases (GTPases) that have been reported to exert broad an...

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Bibliographic Details
Main Authors: Simran Chhabra, Kiran Bala Sharma, Manjula Kalia
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Japanese encephalitis (JE) virus
interferon stimulated genes
guanylate binding protein
STAT 1
interferon gamma (IFNγ)
flavivirus
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.832057/full

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