Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training
Breast cancer (BC) presents a growing global concern, mainly for the female population of working age. Their pathophysiology shows challenges when attempting to ensure conventional treatment efficacy without adverse effects. This study aimed to evaluate the efficacy of magneto-hyperthermia (MHT) the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/3/310 |
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| author | Matheus Haubert Theinel Mariana Penteado Nucci Gabriela Cianciarullo Fernando Anselmo Oliveira Arielly da Hora Alves Javier Bustamante Mamani Gabriel Nery de Albuquerque Rego Nicole Mastandrea Ennes do Valle Olívia Furiama Metropolo Dias Cícero Júlio Silva Costa Felipe Lima Nascimento Juan Matheus Munoz Andressa Arruda de Moraes Lionel Fernel Gamarra |
| author_facet | Matheus Haubert Theinel Mariana Penteado Nucci Gabriela Cianciarullo Fernando Anselmo Oliveira Arielly da Hora Alves Javier Bustamante Mamani Gabriel Nery de Albuquerque Rego Nicole Mastandrea Ennes do Valle Olívia Furiama Metropolo Dias Cícero Júlio Silva Costa Felipe Lima Nascimento Juan Matheus Munoz Andressa Arruda de Moraes Lionel Fernel Gamarra |
| author_sort | Matheus Haubert Theinel |
| collection | DOAJ |
| description | Breast cancer (BC) presents a growing global concern, mainly for the female population of working age. Their pathophysiology shows challenges when attempting to ensure conventional treatment efficacy without adverse effects. This study aimed to evaluate the efficacy of magneto-hyperthermia (MHT) therapy associated with supplementation with omega-3 polyunsaturated fatty acid (w-3 PUFA) and engagement in physical training (PT) for the triple-negative BC (TNBC) model. First, we assessed the physicochemical properties of iron oxide nanoparticles (ION) in biological conditions, as well as their heating potential for MHT therapy. Then, a bioluminescence (BLI) evaluation of the best tumor growth conditions in the TNBC model (the quantity of implanted cells and time), as well as the efficacy of MHT therapy (5 consecutive days) associated with the previous administration of 8 weeks of w-3 PUFA and PT, was carried out. The results showed the good stability and potential of ION for MHT using 300 Gauss and 420 kHz. In the TNBC model, adequate tumor growth was observed after 14 days of 2 × 10<sup>6</sup> cells implantation by BLI. There was a delay in tumor growth in animals that received w-3 and PT and a significant decrease associated with MHT. This pioneering combination therapy approach (MHT, omega-3, and exercise) showed a positive effect on TNBC tumor reduction and demonstrated promise for pre-clinical and clinical studies in the future. |
| first_indexed | 2024-04-24T17:54:49Z |
| format | Article |
| id | doaj.art-357b81a2c07545aaa892a2c25b07d38a |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-24T17:54:49Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-357b81a2c07545aaa892a2c25b07d38a2024-03-27T13:59:34ZengMDPI AGPharmaceutics1999-49232024-02-0116331010.3390/pharmaceutics16030310Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical TrainingMatheus Haubert Theinel0Mariana Penteado Nucci1Gabriela Cianciarullo2Fernando Anselmo Oliveira3Arielly da Hora Alves4Javier Bustamante Mamani5Gabriel Nery de Albuquerque Rego6Nicole Mastandrea Ennes do Valle7Olívia Furiama Metropolo Dias8Cícero Júlio Silva Costa9Felipe Lima Nascimento10Juan Matheus Munoz11Andressa Arruda de Moraes12Lionel Fernel Gamarra13Hospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilLIM44—Hospital das Clínicas da Faculdade Medicina da Universidade de São Paulo, São Paulo 05403-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilHospital Israelita Albert Einstein, São Paulo 05652-000, SP, BrazilBreast cancer (BC) presents a growing global concern, mainly for the female population of working age. Their pathophysiology shows challenges when attempting to ensure conventional treatment efficacy without adverse effects. This study aimed to evaluate the efficacy of magneto-hyperthermia (MHT) therapy associated with supplementation with omega-3 polyunsaturated fatty acid (w-3 PUFA) and engagement in physical training (PT) for the triple-negative BC (TNBC) model. First, we assessed the physicochemical properties of iron oxide nanoparticles (ION) in biological conditions, as well as their heating potential for MHT therapy. Then, a bioluminescence (BLI) evaluation of the best tumor growth conditions in the TNBC model (the quantity of implanted cells and time), as well as the efficacy of MHT therapy (5 consecutive days) associated with the previous administration of 8 weeks of w-3 PUFA and PT, was carried out. The results showed the good stability and potential of ION for MHT using 300 Gauss and 420 kHz. In the TNBC model, adequate tumor growth was observed after 14 days of 2 × 10<sup>6</sup> cells implantation by BLI. There was a delay in tumor growth in animals that received w-3 and PT and a significant decrease associated with MHT. This pioneering combination therapy approach (MHT, omega-3, and exercise) showed a positive effect on TNBC tumor reduction and demonstrated promise for pre-clinical and clinical studies in the future.https://www.mdpi.com/1999-4923/16/3/310omega-3breast cancerpolyunsaturated fattybioluminescence imagingmagnetic-hyperthermiairon oxide nanoparticles |
| spellingShingle | Matheus Haubert Theinel Mariana Penteado Nucci Gabriela Cianciarullo Fernando Anselmo Oliveira Arielly da Hora Alves Javier Bustamante Mamani Gabriel Nery de Albuquerque Rego Nicole Mastandrea Ennes do Valle Olívia Furiama Metropolo Dias Cícero Júlio Silva Costa Felipe Lima Nascimento Juan Matheus Munoz Andressa Arruda de Moraes Lionel Fernel Gamarra Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training Pharmaceutics omega-3 breast cancer polyunsaturated fatty bioluminescence imaging magnetic-hyperthermia iron oxide nanoparticles |
| title | Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training |
| title_full | Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training |
| title_fullStr | Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training |
| title_full_unstemmed | Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training |
| title_short | Breast Cancer Treatment Using the Magneto-Hyperthermia Technique Associated with Omega-3 Polyunsaturated Fatty Acids’ Supplementation and Physical Training |
| title_sort | breast cancer treatment using the magneto hyperthermia technique associated with omega 3 polyunsaturated fatty acids supplementation and physical training |
| topic | omega-3 breast cancer polyunsaturated fatty bioluminescence imaging magnetic-hyperthermia iron oxide nanoparticles |
| url | https://www.mdpi.com/1999-4923/16/3/310 |
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