Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress

Abstract Nucleotide repeat expansions (NREs) are prevalent mutations in a multitude of neurodegenerative diseases. Repeat‐associated non‐AUG (RAN) translation of these repeat regions produces mono or dipeptides that contribute to the pathogenesis of these diseases. However, the mechanisms and driver...

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Bibliographic Details
Main Authors: Thomas Westergard, Kevin McAvoy, Katelyn Russell, Xinmei Wen, Yu Pang, Brandie Morris, Piera Pasinelli, Davide Trotti, Aaron Haeusler
Format: Article
Language:English
Published: Springer Nature 2019-02-01
Series:EMBO Molecular Medicine
Subjects:
ALS
C9orf72
DPR
excitotoxicity
FTD
Online Access:https://doi.org/10.15252/emmm.201809423

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