Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types. Here we used genetic and pharmacological inhibitors to define the pathways involved in PCSK9-mediated LDLR degradation. Inactivating mut...

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Bibliographic Details
Main Authors: Yan Wang, Yongcheng Huang, Helen H. Hobbs, Jonathan C. Cohen
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Journal of Lipid Research
Subjects:
cholesterol
lysosomes
autophagy
endosomes
low density lipoprotein receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520418358

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