Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis

Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis

Francisella tularensis is a facultative intracellular bacterium and the etiological agent of tularemia, a zoonotic disease. Infection of monocytic cells by F. tularensis can be controlled after activation with IFN-γ; however, the molecular mechanisms whereby the control is executed are incompletely...

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Bibliographic Details
Main Authors: Nasibeh Mohammadi, Helena Lindgren, Masahiro Yamamoto, Amandine Martin, Thomas Henry, Anders Sjöstedt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Francisella tularensis
Guanylate-binding proteins
macrophages
cytokine patterns
co-infection
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.784101/full

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