NRAS-driven melanoma: A RAF can hide another
Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, hi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1344758 |
| _version_ | 1797677200058613760 |
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| author | Sabine Druillennec Celio Pouponnot Alain Eychène |
| author_facet | Sabine Druillennec Celio Pouponnot Alain Eychène |
| author_sort | Sabine Druillennec |
| collection | DOAJ |
| description | Using mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, highlighting an addiction to RAF signaling in NRAS-driven melanoma. |
| first_indexed | 2024-03-11T22:41:37Z |
| format | Article |
| id | doaj.art-3580f8ca3fb04b6897b2b04e64ae9c72 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:37Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-3580f8ca3fb04b6897b2b04e64ae9c722023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-11-014610.1080/23723556.2017.13447581344758NRAS-driven melanoma: A RAF can hide anotherSabine Druillennec0Celio Pouponnot1Alain Eychène2Institut CurieInstitut CurieInstitut CurieUsing mouse genetics, we recently showed that BRAF has a critical role in initiation of NRAS-driven melanoma that cannot be compensated by CRAF. In contrast, RAF proteins display compensatory functions in fully established tumors and ARAF can sustain proliferation in the absence of BRAF and CRAF, highlighting an addiction to RAF signaling in NRAS-driven melanoma.http://dx.doi.org/10.1080/23723556.2017.1344758arafbrafcrafrashumanmelanomamouseresistancetumor |
| spellingShingle | Sabine Druillennec Celio Pouponnot Alain Eychène NRAS-driven melanoma: A RAF can hide another Molecular & Cellular Oncology araf braf craf ras human melanoma mouse resistance tumor |
| title | NRAS-driven melanoma: A RAF can hide another |
| title_full | NRAS-driven melanoma: A RAF can hide another |
| title_fullStr | NRAS-driven melanoma: A RAF can hide another |
| title_full_unstemmed | NRAS-driven melanoma: A RAF can hide another |
| title_short | NRAS-driven melanoma: A RAF can hide another |
| title_sort | nras driven melanoma a raf can hide another |
| topic | araf braf craf ras human melanoma mouse resistance tumor |
| url | http://dx.doi.org/10.1080/23723556.2017.1344758 |
| work_keys_str_mv | AT sabinedruillennec nrasdrivenmelanomaarafcanhideanother AT celiopouponnot nrasdrivenmelanomaarafcanhideanother AT alaineychene nrasdrivenmelanomaarafcanhideanother |