Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic
Aim. To determine the level of SARS-CoV-2 seroprevalence among the Novosibirsk Region population against the background of the COVID-19 pandemic. Material and methods. The work was carried out in 2 phases: 1) a cross-sectional cohort study performed 28.06– 15.07.2020; 2) longitudinal cohort 3-stage...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2021-09-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/539/336 |
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| author | A. Yu. Popova V. S. Smirnov E. B. Ezhlova A. A. Mel’nikova L. V. Samoilova L. V. Lyalina E. V. Semenova M. A. Gurskiy E. A. Aksenova T. V. Arbuzova A. A. Totolian |
| author_facet | A. Yu. Popova V. S. Smirnov E. B. Ezhlova A. A. Mel’nikova L. V. Samoilova L. V. Lyalina E. V. Semenova M. A. Gurskiy E. A. Aksenova T. V. Arbuzova A. A. Totolian |
| author_sort | A. Yu. Popova |
| collection | DOAJ |
| description | Aim. To determine the level of SARS-CoV-2 seroprevalence among the Novosibirsk Region population against the background of the COVID-19 pandemic.
Material and methods. The work was carried out in 2 phases: 1) a cross-sectional cohort study performed 28.06– 15.07.2020; 2) longitudinal cohort 3-stage seromonitoring: 1st stage 28.06–15.07.2020; 2nd 14.09–04.10.2020; 3rd 10–30.12.2020 The work was carried out according to a unified methodology developed by Rospotrebnadzor with the participation of St-Petersburg Pasteur Institute, taking into account the recommendations of the WHO. IgG antibodies to the SARS-CoV-2 nucleocapsid protein were detected by ELISA using a kit of reagents produced by the SRCMSB (Obolensk) according to the manufacturer’s instructions. Statistical analysis was performed using Microsoft Excel 2010 and other programs.
Results. The seroprevalence in the region’s population was 9.1% (95% CI 8.0–10.2): maximum in children 14–17 years old (17.6%, 95% CI 12.3–23.9) and persons over 75 years (14.8%, 95% CI 11.4–18.8), minimum among persons 30–39 years old (4.9%, 95% CI 3.0–8.0). Increased rate was noted among the unemployed (15.4%, 95% CI 9.9–17.1) and other individuals (13.0%, 95% CI 8.6–18.5). Seroprevalence was 33.3% (95% CI 16.3–59.0) in COVID-19 convalescents and 19.0% (95% CI 13.9-25.0) in contact persons. More than 94.7% (95% CI 91.2–97.2) of seropositive individuals were asymptomatic. During the serological monitoring, seroprevalence increased from 7.4% (95% CI 6.2–8.9) at 1st stage 1 to 12.4% (95% CI 10.6–14.3) at 2nd , and 31% (95% CI 28.8–33.3) at 3rd stage.
Conclusion. SARS-CoV-2 herd immunity has not reached the threshold level, this does not exclude exacerbation of the epidemic process. |
| first_indexed | 2024-03-13T00:08:29Z |
| format | Article |
| id | doaj.art-3581baebceed4132b2f555aae5ee0956 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:08:29Z |
| publishDate | 2021-09-01 |
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| series | Вопросы вирусологии |
| spelling | doaj.art-3581baebceed4132b2f555aae5ee09562023-07-12T19:56:23ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972021-09-0166429930910.36233/0507-4088-54398Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemicA. Yu. Popova0https://orcid.org/0000-0003-2567-9032V. S. Smirnov1https://orcid.org/0000-0002-2723-1496E. B. Ezhlova2https://orcid.org/0000-0002-8701-280XA. A. Mel’nikova3https://orcid.org/0000-0002-5651-1331L. V. Samoilova4https://orcid.org/0000-0003-4836-9010L. V. Lyalina5https://orcid.org/0000-0001-9921-3505E. V. Semenova6https://orcid.org/0000-0002-7715-7036M. A. Gurskiy7https://orcid.org/0000-0002-5951-0940E. A. Aksenova8https://orcid.org/0000-0001-6515-2169T. V. Arbuzova9https://orcid.org/0000-0002-3074-8656A. A. Totolian10https://orcid.org/0000-0003-4571-8799Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)FBSI «Saint Petersburg Pasteur Research Institute of Epidemiology and Mictobiology» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Administration of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) for the Novosibirsk RegionFBSI «Saint Petersburg Pasteur Research Institute of Epidemiology and Mictobiology» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)FBIH «Center for Hygiene and Epidemiology in the Novosibirsk Region»FBIH «Center for Hygiene and Epidemiology in the Novosibirsk Region»Ministry of Health of the Novosibirsk RegionFBSI «Saint Petersburg Pasteur Research Institute of Epidemiology and Mictobiology» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)FBSI «Saint Petersburg Pasteur Research Institute of Epidemiology and Mictobiology» of the Federal Service for Surveillance of Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)Aim. To determine the level of SARS-CoV-2 seroprevalence among the Novosibirsk Region population against the background of the COVID-19 pandemic. Material and methods. The work was carried out in 2 phases: 1) a cross-sectional cohort study performed 28.06– 15.07.2020; 2) longitudinal cohort 3-stage seromonitoring: 1st stage 28.06–15.07.2020; 2nd 14.09–04.10.2020; 3rd 10–30.12.2020 The work was carried out according to a unified methodology developed by Rospotrebnadzor with the participation of St-Petersburg Pasteur Institute, taking into account the recommendations of the WHO. IgG antibodies to the SARS-CoV-2 nucleocapsid protein were detected by ELISA using a kit of reagents produced by the SRCMSB (Obolensk) according to the manufacturer’s instructions. Statistical analysis was performed using Microsoft Excel 2010 and other programs. Results. The seroprevalence in the region’s population was 9.1% (95% CI 8.0–10.2): maximum in children 14–17 years old (17.6%, 95% CI 12.3–23.9) and persons over 75 years (14.8%, 95% CI 11.4–18.8), minimum among persons 30–39 years old (4.9%, 95% CI 3.0–8.0). Increased rate was noted among the unemployed (15.4%, 95% CI 9.9–17.1) and other individuals (13.0%, 95% CI 8.6–18.5). Seroprevalence was 33.3% (95% CI 16.3–59.0) in COVID-19 convalescents and 19.0% (95% CI 13.9-25.0) in contact persons. More than 94.7% (95% CI 91.2–97.2) of seropositive individuals were asymptomatic. During the serological monitoring, seroprevalence increased from 7.4% (95% CI 6.2–8.9) at 1st stage 1 to 12.4% (95% CI 10.6–14.3) at 2nd , and 31% (95% CI 28.8–33.3) at 3rd stage. Conclusion. SARS-CoV-2 herd immunity has not reached the threshold level, this does not exclude exacerbation of the epidemic process.https://virusjour.crie.ru/jour/article/viewFile/539/336coronavirussars-cov-2covid-19antibodiesseroprevalencenovosibirsk regionpopulation |
| spellingShingle | A. Yu. Popova V. S. Smirnov E. B. Ezhlova A. A. Mel’nikova L. V. Samoilova L. V. Lyalina E. V. Semenova M. A. Gurskiy E. A. Aksenova T. V. Arbuzova A. A. Totolian Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic Вопросы вирусологии coronavirus sars-cov-2 covid-19 antibodies seroprevalence novosibirsk region population |
| title | Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic |
| title_full | Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic |
| title_fullStr | Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic |
| title_full_unstemmed | Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic |
| title_short | Herd immunity to SARS-CoV-2 in the Novosibirsk Region population amid the COVID-19 pandemic |
| title_sort | herd immunity to sars cov 2 in the novosibirsk region population amid the covid 19 pandemic |
| topic | coronavirus sars-cov-2 covid-19 antibodies seroprevalence novosibirsk region population |
| url | https://virusjour.crie.ru/jour/article/viewFile/539/336 |
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