The effect of hyperthyroidism on cognitive function, neuroinflammation, and necroptosis in APP/PS1 mice

The effect of hyperthyroidism on cognitive function, neuroinflammation, and necroptosis in APP/PS1 mice

Abstract Background Increasing evidence has linked the thyroid dysfunction to the pathogenesis of dementia. Evidence from clinical studies has demonstrated that hypothyroidism is related to an increased risk of dementia. But the association of hyperthyroidism with dementia is largely unknown. Method...

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Bibliographic Details
Main Authors: Kai Lou, Shudong Liu, Fengxia Zhang, Wenxiu Sun, Xinhuan Su, Wenkai Bi, Qingqing Yin, Yaxin Qiu, Zhenyuan Zhang, Mengzhe Jing, Shizhan Ma
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Translational Medicine
Subjects:
Alzheimer’s disease
Graves’ disease
Single cell RNA-sequencing
Neuroinflammation
Necroptosis
Online Access:https://doi.org/10.1186/s12967-023-04511-x

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