Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length.
We most often consider muscle as a motor generating force in the direction of shortening, but less often consider its roles as a spring or a brake. Here we develop a fully three-dimensional spatially explicit model of muscle to isolate the locations of forces and energies that are difficult to separ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC3499250?pdf=render |
| _version_ | 1818989669285625856 |
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| author | C David Williams Michael Regnier Thomas L Daniel |
| author_facet | C David Williams Michael Regnier Thomas L Daniel |
| author_sort | C David Williams |
| collection | DOAJ |
| description | We most often consider muscle as a motor generating force in the direction of shortening, but less often consider its roles as a spring or a brake. Here we develop a fully three-dimensional spatially explicit model of muscle to isolate the locations of forces and energies that are difficult to separate experimentally. We show the strain energy in the thick and thin filaments is less than one third the strain energy in attached cross-bridges. This result suggests the cross-bridges act as springs, storing energy within muscle in addition to generating the force which powers muscle. Comparing model estimates of energy consumed to elastic energy stored, we show that the ratio of these two properties changes with sarcomere length. The model predicts storage of a greater fraction of energy at short sarcomere lengths, suggesting a mechanism by which muscle function shifts as force production declines, from motor to spring. Additionally, we investigate the force that muscle produces in the radial or transverse direction, orthogonal to the direction of shortening. We confirm prior experimental estimates that place radial forces on the same order of magnitude as axial forces, although we find that radial forces and axial forces vary differently with changes in sarcomere length. |
| first_indexed | 2024-12-20T19:42:09Z |
| format | Article |
| id | doaj.art-35832767c2924f70826fe6fafb5b559b |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-20T19:42:09Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-35832767c2924f70826fe6fafb5b559b2022-12-21T19:28:29ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582012-01-01811e100277010.1371/journal.pcbi.1002770Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length.C David WilliamsMichael RegnierThomas L DanielWe most often consider muscle as a motor generating force in the direction of shortening, but less often consider its roles as a spring or a brake. Here we develop a fully three-dimensional spatially explicit model of muscle to isolate the locations of forces and energies that are difficult to separate experimentally. We show the strain energy in the thick and thin filaments is less than one third the strain energy in attached cross-bridges. This result suggests the cross-bridges act as springs, storing energy within muscle in addition to generating the force which powers muscle. Comparing model estimates of energy consumed to elastic energy stored, we show that the ratio of these two properties changes with sarcomere length. The model predicts storage of a greater fraction of energy at short sarcomere lengths, suggesting a mechanism by which muscle function shifts as force production declines, from motor to spring. Additionally, we investigate the force that muscle produces in the radial or transverse direction, orthogonal to the direction of shortening. We confirm prior experimental estimates that place radial forces on the same order of magnitude as axial forces, although we find that radial forces and axial forces vary differently with changes in sarcomere length.http://europepmc.org/articles/PMC3499250?pdf=render |
| spellingShingle | C David Williams Michael Regnier Thomas L Daniel Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. PLoS Computational Biology |
| title | Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. |
| title_full | Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. |
| title_fullStr | Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. |
| title_full_unstemmed | Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. |
| title_short | Elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length. |
| title_sort | elastic energy storage and radial forces in the myofilament lattice depend on sarcomere length |
| url | http://europepmc.org/articles/PMC3499250?pdf=render |
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