Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service
Among the malignancies, colorectal cancer ranks fourth in incidence in Brazil. The main prognostic measure is related to the amount of affected lymph nodes. Thus, many studies try to correlate the number of extracted lymph nodes, with the probability of obtaining positive nodes. Study objectives: De...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações Ltda.
2016-10-01
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| Series: | Journal of Coloproctology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S223793631630065X |
| _version_ | 1818667103728697344 |
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| author | Murilo Zomer Frasson Kaiser S. Kock Letícia F. Monteiro Jonas V. Romagna |
| author_facet | Murilo Zomer Frasson Kaiser S. Kock Letícia F. Monteiro Jonas V. Romagna |
| author_sort | Murilo Zomer Frasson |
| collection | DOAJ |
| description | Among the malignancies, colorectal cancer ranks fourth in incidence in Brazil. The main prognostic measure is related to the amount of affected lymph nodes. Thus, many studies try to correlate the number of extracted lymph nodes, with the probability of obtaining positive nodes. Study objectives: Determine whether dissection ≥12 lymph nodes increases probability of finding neoplastic involvement in relation to resection of fewer. Assess the presence of angiolymphatic invasion; perineural and intracelluar mucin and correlate it with tumor differentiation and TNM classification. Correlate the average of positive nodes with angiolymphatic and perineural involvement. Methods: Pathological reports of patients operated for CRC from 1997 to 2013 were analyzed. A probability (p) less than 0.05 was considered to indicate statistical significance. Results: Median of lymph nodes sent to analysis was 12 nodes. Average number of lymph nodes affected was higher when a number ≥12 lymph nodes were dissected (p = 0.001) (Kruskal–Wallis). There was positive association between average of affected lymph nodes and presence of angiolymphatic (p < 0.0001) or perineural invasion (p = 0.024). Angiolymphatic and intracellular mucin are less present in well-differentiated adenocarcinomas. Perineural and angiolymphatic were more present in T4 stages. Conclusions: Dissection ≥12 lymph nodes increases chances of finding positive nodes. There is relation between angiolymphatic invasion; perineural and intracellular mucin and type of tumor differentiation, as well as TNM classification. Average number of lymph nodes affected was higher in presence of perineural or angiolymphatic invasion. Resumo: Dentre as neoplasias malignas, o câncer colorretal ocupa o quarto lugar em incidência no Brasil. Uma das principais medidas de prognóstico está relacionada à quantidade de linfonodos acometidos. Sendo assim, muitos trabalhos estudam meios de correlacionar o número de linfonodos dissecados, com a probabilidade de se obterem linfonodos positivos. Objetivos do estudo: Determinar se a dissecção ≥ 12 linfonodos aumenta a probabilidade de se encontrar acometimento neoplásico nos mesmos em relação à menor ressecção. Avaliar a presença de invasão angiolinfática; perineural e mucina intracelular e correlacioná-la com diferenciação tumoral e classificação TNM. Correlacionar a média de nodos positivos com acometimento angiolinfático e perineural. Métodos: Foram analisados laudos anatomopatológicos de pacientes operados por câncer colorretal (CCR) de 1997 a 2013. A probabilidade (p) menor que 0,05 foi considerada para indicar significância estatística. Resultados: A média de linfonodos comprometidos foi maior quando um número ≥ 12 linfonodos foram dissecados (p = 0,001) (Kruskal-Wallis). Houve associação positiva entre a média de linfonodos afetados e a presença de invasão angiolinfática (p < 0,0001) ou perineural (p = 0,024). A invasão angiolinfática e a mucina intracelular estavam menos presentes em adenocarcinomas bem diferenciados. Invasão perineural e angiolinfática estiveram mais presentes nos estádios T4. Conclusões: A dissecção ≥ 12 linfonodos aumenta as chances de se encontrar nodo positivo. Existe relação entre invasão angiolinfática; perineural e mucina intracelular e o tipo de diferenciação tumoral, bem como a classificação TNM. A média de linfonodos comprometidos foi maior na presença de invasão perineural ou angiolinfática. Keywords: Colorectal neoplasms, Lymph nodes, Lymph node excision, Palavras-chave: Neoplasias colorretais, Linfonodos, Excisão de linfonodo |
| first_indexed | 2024-12-17T06:15:06Z |
| format | Article |
| id | doaj.art-3584416ec797402b859acf36c4a4fbef |
| institution | Directory Open Access Journal |
| issn | 2237-9363 |
| language | English |
| last_indexed | 2024-12-17T06:15:06Z |
| publishDate | 2016-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Journal of Coloproctology |
| spelling | doaj.art-3584416ec797402b859acf36c4a4fbef2022-12-21T22:00:32ZengThieme Revinter Publicações Ltda.Journal of Coloproctology2237-93632016-10-01364220226Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral serviceMurilo Zomer Frasson0Kaiser S. Kock1Letícia F. Monteiro2Jonas V. Romagna3Corresponding author.; Universidade do Sul de Santa Catarina, Tubarão, SC, BrazilUniversidade do Sul de Santa Catarina, Tubarão, SC, BrazilUniversidade do Sul de Santa Catarina, Tubarão, SC, BrazilUniversidade do Sul de Santa Catarina, Tubarão, SC, BrazilAmong the malignancies, colorectal cancer ranks fourth in incidence in Brazil. The main prognostic measure is related to the amount of affected lymph nodes. Thus, many studies try to correlate the number of extracted lymph nodes, with the probability of obtaining positive nodes. Study objectives: Determine whether dissection ≥12 lymph nodes increases probability of finding neoplastic involvement in relation to resection of fewer. Assess the presence of angiolymphatic invasion; perineural and intracelluar mucin and correlate it with tumor differentiation and TNM classification. Correlate the average of positive nodes with angiolymphatic and perineural involvement. Methods: Pathological reports of patients operated for CRC from 1997 to 2013 were analyzed. A probability (p) less than 0.05 was considered to indicate statistical significance. Results: Median of lymph nodes sent to analysis was 12 nodes. Average number of lymph nodes affected was higher when a number ≥12 lymph nodes were dissected (p = 0.001) (Kruskal–Wallis). There was positive association between average of affected lymph nodes and presence of angiolymphatic (p < 0.0001) or perineural invasion (p = 0.024). Angiolymphatic and intracellular mucin are less present in well-differentiated adenocarcinomas. Perineural and angiolymphatic were more present in T4 stages. Conclusions: Dissection ≥12 lymph nodes increases chances of finding positive nodes. There is relation between angiolymphatic invasion; perineural and intracellular mucin and type of tumor differentiation, as well as TNM classification. Average number of lymph nodes affected was higher in presence of perineural or angiolymphatic invasion. Resumo: Dentre as neoplasias malignas, o câncer colorretal ocupa o quarto lugar em incidência no Brasil. Uma das principais medidas de prognóstico está relacionada à quantidade de linfonodos acometidos. Sendo assim, muitos trabalhos estudam meios de correlacionar o número de linfonodos dissecados, com a probabilidade de se obterem linfonodos positivos. Objetivos do estudo: Determinar se a dissecção ≥ 12 linfonodos aumenta a probabilidade de se encontrar acometimento neoplásico nos mesmos em relação à menor ressecção. Avaliar a presença de invasão angiolinfática; perineural e mucina intracelular e correlacioná-la com diferenciação tumoral e classificação TNM. Correlacionar a média de nodos positivos com acometimento angiolinfático e perineural. Métodos: Foram analisados laudos anatomopatológicos de pacientes operados por câncer colorretal (CCR) de 1997 a 2013. A probabilidade (p) menor que 0,05 foi considerada para indicar significância estatística. Resultados: A média de linfonodos comprometidos foi maior quando um número ≥ 12 linfonodos foram dissecados (p = 0,001) (Kruskal-Wallis). Houve associação positiva entre a média de linfonodos afetados e a presença de invasão angiolinfática (p < 0,0001) ou perineural (p = 0,024). A invasão angiolinfática e a mucina intracelular estavam menos presentes em adenocarcinomas bem diferenciados. Invasão perineural e angiolinfática estiveram mais presentes nos estádios T4. Conclusões: A dissecção ≥ 12 linfonodos aumenta as chances de se encontrar nodo positivo. Existe relação entre invasão angiolinfática; perineural e mucina intracelular e o tipo de diferenciação tumoral, bem como a classificação TNM. A média de linfonodos comprometidos foi maior na presença de invasão perineural ou angiolinfática. Keywords: Colorectal neoplasms, Lymph nodes, Lymph node excision, Palavras-chave: Neoplasias colorretais, Linfonodos, Excisão de linfonodohttp://www.sciencedirect.com/science/article/pii/S223793631630065X |
| spellingShingle | Murilo Zomer Frasson Kaiser S. Kock Letícia F. Monteiro Jonas V. Romagna Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service Journal of Coloproctology |
| title | Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service |
| title_full | Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service |
| title_fullStr | Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service |
| title_full_unstemmed | Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service |
| title_short | Number of lymph nodes dissected in colorectal cancer and probability of positive nodes, angiolymphatic/perineural invasion, and intracellular mucin in a referral service |
| title_sort | number of lymph nodes dissected in colorectal cancer and probability of positive nodes angiolymphatic perineural invasion and intracellular mucin in a referral service |
| url | http://www.sciencedirect.com/science/article/pii/S223793631630065X |
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