Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action
Malaria is one of the most life-threatening infectious diseases and constitutes a major health problem, especially in Africa. Although artemisinin combination therapies remain efficacious to treat malaria, the emergence of resistant parasites emphasizes the urgent need of new alternative chemotherap...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/8/2304 |
| _version_ | 1797537509667766272 |
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| author | Lais Pessanha de Carvalho Andrea Kreidenweiss Jana Held |
| author_facet | Lais Pessanha de Carvalho Andrea Kreidenweiss Jana Held |
| author_sort | Lais Pessanha de Carvalho |
| collection | DOAJ |
| description | Malaria is one of the most life-threatening infectious diseases and constitutes a major health problem, especially in Africa. Although artemisinin combination therapies remain efficacious to treat malaria, the emergence of resistant parasites emphasizes the urgent need of new alternative chemotherapies. One strategy is the repurposing of existing drugs. Herein, we reviewed the antimalarial effects of marketed antibiotics, and described in detail the fast-acting antibiotics that showed activity in nanomolar concentrations. Antibiotics have been used for prophylaxis and treatment of malaria for many years and are of particular interest because they might exert a different mode of action than current antimalarials, and can be used simultaneously to treat concomitant bacterial infections. |
| first_indexed | 2024-03-10T12:17:08Z |
| format | Article |
| id | doaj.art-358947099e564d1980836fac86664794 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:17:08Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-358947099e564d1980836fac866647942023-11-21T15:46:43ZengMDPI AGMolecules1420-30492021-04-01268230410.3390/molecules26082304Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial ActionLais Pessanha de Carvalho0Andrea Kreidenweiss1Jana Held2Institute of Tropical Medicine, University of Tuebingen, 72074 Tuebingen, GermanyInstitute of Tropical Medicine, University of Tuebingen, 72074 Tuebingen, GermanyInstitute of Tropical Medicine, University of Tuebingen, 72074 Tuebingen, GermanyMalaria is one of the most life-threatening infectious diseases and constitutes a major health problem, especially in Africa. Although artemisinin combination therapies remain efficacious to treat malaria, the emergence of resistant parasites emphasizes the urgent need of new alternative chemotherapies. One strategy is the repurposing of existing drugs. Herein, we reviewed the antimalarial effects of marketed antibiotics, and described in detail the fast-acting antibiotics that showed activity in nanomolar concentrations. Antibiotics have been used for prophylaxis and treatment of malaria for many years and are of particular interest because they might exert a different mode of action than current antimalarials, and can be used simultaneously to treat concomitant bacterial infections.https://www.mdpi.com/1420-3049/26/8/2304antibioticsdrug repurposingmalariaPlasmodiumslow and fast-acting drugs |
| spellingShingle | Lais Pessanha de Carvalho Andrea Kreidenweiss Jana Held Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action Molecules antibiotics drug repurposing malaria Plasmodium slow and fast-acting drugs |
| title | Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action |
| title_full | Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action |
| title_fullStr | Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action |
| title_full_unstemmed | Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action |
| title_short | Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action |
| title_sort | drug repurposing a review of old and new antibiotics for the treatment of malaria identifying antibiotics with a fast onset of antiplasmodial action |
| topic | antibiotics drug repurposing malaria Plasmodium slow and fast-acting drugs |
| url | https://www.mdpi.com/1420-3049/26/8/2304 |
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