Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children [version 2; referees: 1 approved, 3 approved with reservations]

Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children [version 2; referees: 1 approved, 3 approved with reservations]

We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC–ESI-MS/MS) for the simultaneous quantitation of ceftriaxone (CEF), metronidazole (MET) and hydroxym...

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Bibliographic Details
Main Authors: Martin Ongas, Joseph Standing, Bernhards Ogutu, Joseph Waichungo, James A. Berkley, Karin Kipper
Format: Article
Language:English
Published: Wellcome 2018-01-01
Series:Wellcome Open Research
Subjects:
Methods for Diagnostic & Therapeutic Studies
Online Access:https://wellcomeopenresearch.org/articles/2-43/v2

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