Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides

Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides

The delivery of cancer therapeutics can be limited by pharmacological issues such as poor bioavailability and high toxicity to healthy tissue. pH-low insertion peptides (pHLIPs) represent a promising tool to overcome these limitations. pHLIPs allow for the selective delivery of agents to tumors on t...

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Bibliographic Details
Main Authors: Nayanthara U. Dharmaratne, Alanna R. Kaplan, Peter M. Glazer
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
hypoxia
acidity
pHLIP
tumor targeting
peptide nucleic acids
toxins
Online Access:https://www.mdpi.com/2073-4409/10/3/541

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