Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer

Insonation of Systemically Delivered Cisplatin-Loaded Microbubbles Significantly Attenuates Nephrotoxicity of Chemotherapy in Experimental Models of Head and Neck Cancer

The use of cisplatin (CDDP), the most common chemotherapy drug for head and neck cancer, is limited by its undesirable side effects, especially nephrotoxicity. We investigated ultrasound microbubbles (USMB) as a tool to increase the local intra-tumoral CDDP level while decreasing systemic CDDP cytot...

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Bibliographic Details
Main Authors: Hang-Kang Chen, Shu-Mei Zhang, Junn-Liang Chang, Hsin-Chien Chen, Yi-Chun Lin, Cheng-Ping Shih, Huey-Kang Sytwu, Mei-Cho Fang, Yuan-Yung Lin, Chao-Yin Kuo, Ai-Ho Liao, Yueng-Hsiang Chu, Chih-Hung Wang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
ultrasound
microbubble
cisplatin
nephrotoxicity
head and neck cancer
chemotherapy
Online Access:http://www.mdpi.com/2072-6694/10/9/311

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