Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma

Detection of circulating tumor DNA without a tumor-informed search using next-generation sequencing is a prognostic biomarker in pancreatic ductal adenocarcinoma

The confounding effects of next-generation sequencing (NGS) noise on detection of low frequency circulating tumor DNA (ctDNA) without a priori knowledge of solid tumor mutations has limited the applications of circulating cell-free DNA (ccfDNA) in clinical oncology. Here, we use a 118 gene panel and...

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Bibliographic Details
Main Authors: Kajsa E. Affolter, Sabine Hellwig, David A. Nix, Mary P. Bronner, Alun Thomas, Carrie L. Fuertes, Cindy L. Hamil, Ignacio Garrido-Laguna, Courtney L. Scaife, Sean J. Mulvihill, Hunter R. Underhill
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Pancreatic ductal adenocarcinoma
Next-generation sequencing
Cell-free DNA
Circulating tumor DNA
Biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000452

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