Anticancer sulfonamide hybrids that inhibit bladder cancer cells growth and migration as tubulin polymerisation inhibitors

Anticancer sulfonamide hybrids that inhibit bladder cancer cells growth and migration as tubulin polymerisation inhibitors

Novel sulfonamide-dithiocarbamate hybrids were designed and synthesised via the molecular hybridisation strategy. Among them, compound 13d displayed a potent activity with IC50 values of 0.9, 0.7, 1.9 and 2.6 µM against UM-UC-3, RT-112, RT4 and T24. Compound 13d inhibited the migration and regulated...

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Bibliographic Details
Main Authors:	Jia Liu, Chunlai Liu, Xiling Zhang, Liu Yu, Xue Gong, Ping Wang
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	sulfonamide-dithiocarbamate rt-112 cell migration tubulin polymerisation antitumor
Online Access:	http://dx.doi.org/10.1080/14756366.2019.1639696

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