Effect of treatment of depression and anxiety on physiological state of severe COPD patients
Background: Anxiety and depression are mental health problems that result in reduced health-related quality of life (HRQL), and increased mortality. Patients with COPD have a higher risk of anxiety and depression compared to healthy individuals. Recent studies reported a significant relationship bet...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763814001770 |
| _version_ | 1818390104727617536 |
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| author | Osama M. Momtaz Salwa M. Rabei Nezar R. Tawfike Ali A. Hasan |
| author_facet | Osama M. Momtaz Salwa M. Rabei Nezar R. Tawfike Ali A. Hasan |
| author_sort | Osama M. Momtaz |
| collection | DOAJ |
| description | Background: Anxiety and depression are mental health problems that result in reduced health-related quality of life (HRQL), and increased mortality. Patients with COPD have a higher risk of anxiety and depression compared to healthy individuals. Recent studies reported a significant relationship between the presence of anxiety and depression and the functional status of COPD patients.
Objectives: To study the effect of treatment of anxiety and depression on the physiological status in COPD patients.
Materials and methods: The study included 50 severe COPD patients with depression and/or anxiety as evaluated and scored by Montgomery and Asberg Depression Rating Scale (MADRS) and Hamilton Anxiety Rating (HAM-A) Scale. They were classified into 2 groups: group I included 25 patients who received antidepressant/anxiolytic therapy in addition to COPD treatment and group II included 25 patients who received COPD treatment only. Modified Borg scale dyspnea score, spirometry (vital capacity, forced vital capacity, forced expiratory volume in first second and forced expiratory flow through 25–75% of expiration), arterial blood, MADRS and HAM-A scale were assessed in all patients at the start of the study and after 3 months.
Results: Patients with severe COPD who were treated for depression and/or anxiety showed a significant improvement in MADRS, HAM-A and dyspnea scales, spirometeric parameters and oxygenation. MADRS and HAM-A scale showed a significant negative correlation to FEV1.
Conclusion: Treatment of depression and anxiety in COPD patients is recommended as it is associated with a significant improvement in pulmonary physiological status and HRQL. Further studies on larger scales are recommended. |
| first_indexed | 2024-12-14T04:52:20Z |
| format | Article |
| id | doaj.art-358b370a841d42af9deffcbe8fa881f7 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-14T04:52:20Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-358b370a841d42af9deffcbe8fa881f72022-12-21T23:16:30ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382015-01-01641293410.1016/j.ejcdt.2014.08.006Effect of treatment of depression and anxiety on physiological state of severe COPD patientsOsama M. Momtaz0Salwa M. Rabei1Nezar R. Tawfike2Ali A. Hasan3Critical Care Department, Faculty of Medicine, El-Minia University, EgyptPsychiatry Department, Faculty of Medicine, El-Minia University, EgyptChest Department, Faculty of Medicine, El-Minia University, EgyptChest Department, Faculty of Medicine, Assiut University, EgyptBackground: Anxiety and depression are mental health problems that result in reduced health-related quality of life (HRQL), and increased mortality. Patients with COPD have a higher risk of anxiety and depression compared to healthy individuals. Recent studies reported a significant relationship between the presence of anxiety and depression and the functional status of COPD patients. Objectives: To study the effect of treatment of anxiety and depression on the physiological status in COPD patients. Materials and methods: The study included 50 severe COPD patients with depression and/or anxiety as evaluated and scored by Montgomery and Asberg Depression Rating Scale (MADRS) and Hamilton Anxiety Rating (HAM-A) Scale. They were classified into 2 groups: group I included 25 patients who received antidepressant/anxiolytic therapy in addition to COPD treatment and group II included 25 patients who received COPD treatment only. Modified Borg scale dyspnea score, spirometry (vital capacity, forced vital capacity, forced expiratory volume in first second and forced expiratory flow through 25–75% of expiration), arterial blood, MADRS and HAM-A scale were assessed in all patients at the start of the study and after 3 months. Results: Patients with severe COPD who were treated for depression and/or anxiety showed a significant improvement in MADRS, HAM-A and dyspnea scales, spirometeric parameters and oxygenation. MADRS and HAM-A scale showed a significant negative correlation to FEV1. Conclusion: Treatment of depression and anxiety in COPD patients is recommended as it is associated with a significant improvement in pulmonary physiological status and HRQL. Further studies on larger scales are recommended.http://www.sciencedirect.com/science/article/pii/S0422763814001770COPDAnxietyDepression |
| spellingShingle | Osama M. Momtaz Salwa M. Rabei Nezar R. Tawfike Ali A. Hasan Effect of treatment of depression and anxiety on physiological state of severe COPD patients Egyptian Journal of Chest Disease and Tuberculosis COPD Anxiety Depression |
| title | Effect of treatment of depression and anxiety on physiological state of severe COPD patients |
| title_full | Effect of treatment of depression and anxiety on physiological state of severe COPD patients |
| title_fullStr | Effect of treatment of depression and anxiety on physiological state of severe COPD patients |
| title_full_unstemmed | Effect of treatment of depression and anxiety on physiological state of severe COPD patients |
| title_short | Effect of treatment of depression and anxiety on physiological state of severe COPD patients |
| title_sort | effect of treatment of depression and anxiety on physiological state of severe copd patients |
| topic | COPD Anxiety Depression |
| url | http://www.sciencedirect.com/science/article/pii/S0422763814001770 |
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