Macrophages as a Source and Recipient of Wnt Signals
Macrophages are often viewed through the lens of their core functions, but recent transcriptomic studies reveal them to be largely distinct across tissue types. While these differences appear to be shaped by their local environment, the key signals that drive these transcriptional differences remain...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01813/full |
| _version_ | 1818507274471079936 |
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| author | Elizabeth S. Malsin Seokjo Kim Anna P. Lam Cara J. Gottardi |
| author_facet | Elizabeth S. Malsin Seokjo Kim Anna P. Lam Cara J. Gottardi |
| author_sort | Elizabeth S. Malsin |
| collection | DOAJ |
| description | Macrophages are often viewed through the lens of their core functions, but recent transcriptomic studies reveal them to be largely distinct across tissue types. While these differences appear to be shaped by their local environment, the key signals that drive these transcriptional differences remain unclear. Since Wnt signaling plays established roles in cell fate decisions, and tissue patterning during development and tissue repair after injury, we consider evidence that Wnt signals both target and are affected by macrophage functions. We propose that the Wnt gradients present in developing and adult tissues effectively shape macrophage fates and phenotypes. We also highlight evidence that macrophages, through an ability to dispatch Wnt signals, may couple tissue debridement and matrix remodeling with stem cell activation and tissue repair. |
| first_indexed | 2024-12-10T22:16:12Z |
| format | Article |
| id | doaj.art-358c81f41cb344f2aef97491fc502301 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T22:16:12Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-358c81f41cb344f2aef97491fc5023012022-12-22T01:31:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01813464433Macrophages as a Source and Recipient of Wnt SignalsElizabeth S. MalsinSeokjo KimAnna P. LamCara J. GottardiMacrophages are often viewed through the lens of their core functions, but recent transcriptomic studies reveal them to be largely distinct across tissue types. While these differences appear to be shaped by their local environment, the key signals that drive these transcriptional differences remain unclear. Since Wnt signaling plays established roles in cell fate decisions, and tissue patterning during development and tissue repair after injury, we consider evidence that Wnt signals both target and are affected by macrophage functions. We propose that the Wnt gradients present in developing and adult tissues effectively shape macrophage fates and phenotypes. We also highlight evidence that macrophages, through an ability to dispatch Wnt signals, may couple tissue debridement and matrix remodeling with stem cell activation and tissue repair.https://www.frontiersin.org/article/10.3389/fimmu.2019.01813/fullmacrophagesmonocytesbeta cateninWnt signalingimmunity |
| spellingShingle | Elizabeth S. Malsin Seokjo Kim Anna P. Lam Cara J. Gottardi Macrophages as a Source and Recipient of Wnt Signals Frontiers in Immunology macrophages monocytes beta catenin Wnt signaling immunity |
| title | Macrophages as a Source and Recipient of Wnt Signals |
| title_full | Macrophages as a Source and Recipient of Wnt Signals |
| title_fullStr | Macrophages as a Source and Recipient of Wnt Signals |
| title_full_unstemmed | Macrophages as a Source and Recipient of Wnt Signals |
| title_short | Macrophages as a Source and Recipient of Wnt Signals |
| title_sort | macrophages as a source and recipient of wnt signals |
| topic | macrophages monocytes beta catenin Wnt signaling immunity |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01813/full |
| work_keys_str_mv | AT elizabethsmalsin macrophagesasasourceandrecipientofwntsignals AT seokjokim macrophagesasasourceandrecipientofwntsignals AT annaplam macrophagesasasourceandrecipientofwntsignals AT carajgottardi macrophagesasasourceandrecipientofwntsignals |