Development and optimization of a sensitive pseudovirus-based assay for HIV-1 neutralizing antibodies detection using A3R5 cells

Development and optimization of a sensitive pseudovirus-based assay for HIV-1 neutralizing antibodies detection using A3R5 cells

Sensitive assays for HIV-1 neutralizing antibody detection are urgently needed for vaccine immunogen optimization and identification of protective immune response levels. In this study, we developed an easy-to-use HIV-1 pseudovirus neutralization assay based on a human CD4+ lymphoblastoid cell line...

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Bibliographic Details
Main Authors: Qingqing Chen, Jianhui Nie, Weijin Huang, Yanmei Jiao, Lan Li, Tong Zhang, Juan Zhao, Hao Wu, Youchun Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
hiv-1
neutralizing antibody
pseudovirus
a3r5
tzm-bl
Online Access:http://dx.doi.org/10.1080/21645515.2017.1373922

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