Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients
Neveen E Sorour,1 Fatma M Elesawy,1 Hala A Tabl,2 Mohammed E Ibrahim,3 Essam M Akl1 1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt; 2Department of Microbiology and Immunology, Faculty of Medicine, Benha University, Benha, Egypt; 3Department...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-02-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/evaluation-of-serum-levels-of-neurotrophin-4-and-brain-derived-nerve-g-peer-reviewed-article-CCID |
| _version_ | 1817995941005754368 |
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| author | Sorour NE Elesawy FM Tabl HA Ibrahim ME Akl EM |
| author_facet | Sorour NE Elesawy FM Tabl HA Ibrahim ME Akl EM |
| author_sort | Sorour NE |
| collection | DOAJ |
| description | Neveen E Sorour,1 Fatma M Elesawy,1 Hala A Tabl,2 Mohammed E Ibrahim,3 Essam M Akl1 1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt; 2Department of Microbiology and Immunology, Faculty of Medicine, Benha University, Benha, Egypt; 3Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, Egypt Background: Pruritus is a common symptom in end-stage renal failure. Many patients suffer from this severe distressing symptom. Although several factors have been postulated to explain uremic pruritus, there is not any conclusive evidence for one of these factors.Objectives: We aimed to evaluate serum levels of brain-derived nerve growth factor (BDNF), neurotrophin-4 (NT-4), serum calcium, phosphors and parathyroid hormone in uremic patients with pruritus and without pruritus compared to control subjects.Methods: One hundred twenty patients suffering from renal failure and 60 healthy subjects were included in the study. Serum BDNF and NT4 levels were determined by ELISA. The serum calcium, phosphorus, parathyroid hormone and hemoglobin were also evaluated.Results: Serum BDNF was significantly higher in uremic patients with pruritus (P=0.0026) and uremic patients without pruritus (P=0.0294) than control subjects. In addition, NT-4 levels were significantly elevated in uremic patients with pruritus (P<0.0001) and uremic patients without pruritus than control subjects (P=0.0016). There was no significant difference of serum level of BDNF between uremic patients with pruritus and uremic patients without pruritus (P=0.1215). However, serum NT-4 was higher in uremic patients with pruritus vs nonpruritic uremic patients with a significant difference (P=0.0026). There was a positive significant correlation between serum level of NT-4 and severity of pruritus (P=0.024).Conclusion: The present study shows that NT-4 level is increased in the serum of uremic patients with pruritus and there was a significant correlation between NT-4 and severity of pruritus suggesting that NT-4 may have a role in uremic pruritus. Keywords: brain-derived neurotrophic factor, neurotrophin-4, uremic pruritus |
| first_indexed | 2024-04-14T02:14:18Z |
| format | Article |
| id | doaj.art-358d7353787b49d0bb51d54c7650fa1d |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-04-14T02:14:18Z |
| publishDate | 2019-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-358d7353787b49d0bb51d54c7650fa1d2022-12-22T02:18:16ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152019-02-01Volume 1210911443978Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patientsSorour NEElesawy FMTabl HAIbrahim MEAkl EMNeveen E Sorour,1 Fatma M Elesawy,1 Hala A Tabl,2 Mohammed E Ibrahim,3 Essam M Akl1 1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt; 2Department of Microbiology and Immunology, Faculty of Medicine, Benha University, Benha, Egypt; 3Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, Egypt Background: Pruritus is a common symptom in end-stage renal failure. Many patients suffer from this severe distressing symptom. Although several factors have been postulated to explain uremic pruritus, there is not any conclusive evidence for one of these factors.Objectives: We aimed to evaluate serum levels of brain-derived nerve growth factor (BDNF), neurotrophin-4 (NT-4), serum calcium, phosphors and parathyroid hormone in uremic patients with pruritus and without pruritus compared to control subjects.Methods: One hundred twenty patients suffering from renal failure and 60 healthy subjects were included in the study. Serum BDNF and NT4 levels were determined by ELISA. The serum calcium, phosphorus, parathyroid hormone and hemoglobin were also evaluated.Results: Serum BDNF was significantly higher in uremic patients with pruritus (P=0.0026) and uremic patients without pruritus (P=0.0294) than control subjects. In addition, NT-4 levels were significantly elevated in uremic patients with pruritus (P<0.0001) and uremic patients without pruritus than control subjects (P=0.0016). There was no significant difference of serum level of BDNF between uremic patients with pruritus and uremic patients without pruritus (P=0.1215). However, serum NT-4 was higher in uremic patients with pruritus vs nonpruritic uremic patients with a significant difference (P=0.0026). There was a positive significant correlation between serum level of NT-4 and severity of pruritus (P=0.024).Conclusion: The present study shows that NT-4 level is increased in the serum of uremic patients with pruritus and there was a significant correlation between NT-4 and severity of pruritus suggesting that NT-4 may have a role in uremic pruritus. Keywords: brain-derived neurotrophic factor, neurotrophin-4, uremic pruritushttps://www.dovepress.com/evaluation-of-serum-levels-of-neurotrophin-4-and-brain-derived-nerve-g-peer-reviewed-article-CCIDBrain-Derived Neurotrophic FactorNeurotrophin-4Uremic Pruritus |
| spellingShingle | Sorour NE Elesawy FM Tabl HA Ibrahim ME Akl EM Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients Clinical, Cosmetic and Investigational Dermatology Brain-Derived Neurotrophic Factor Neurotrophin-4 Uremic Pruritus |
| title | Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients |
| title_full | Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients |
| title_fullStr | Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients |
| title_full_unstemmed | Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients |
| title_short | Evaluation of serum levels of neurotrophin 4 and brain-derived nerve growth factor in uremic pruritus patients |
| title_sort | evaluation of serum levels of neurotrophin 4 and brain derived nerve growth factor in uremic pruritus patients |
| topic | Brain-Derived Neurotrophic Factor Neurotrophin-4 Uremic Pruritus |
| url | https://www.dovepress.com/evaluation-of-serum-levels-of-neurotrophin-4-and-brain-derived-nerve-g-peer-reviewed-article-CCID |
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