The Role of CD44 in Disease Pathophysiology And Targeted Treatment

The Role of CD44 in Disease Pathophysiology And Targeted Treatment

The cell-surface glycoprotein CD44 is involved in a multitude of important physiological functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte activation. The diverse physiological activity of CD44 is manifested in the pathology of a number of diseases including...

Full description

Bibliographic Details
Main Authors:	Andre R. Jordan, Ronny R. Racine, Martin JP Hennig, Vinata B. Lokeshwar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-04-01
Series:	Frontiers in Immunology
Subjects:	Hyaluronic Acid CD44 Hyaluronidase CD44-Signaling CD44 Targeted Therapy
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00182/full

Similar Items

CD44 In Sarcomas: A Comprehensive Review and Future Perspectives
by: Enrique Fernández-Tabanera, et al.
Published: (2022-06-01)

CD44 Expression Profile Varies According to Maturational Subtypes and Molecular Profiles of Pediatric T-Cell Lymphoblastic Leukemia
by: Luísa Vieira Codeço Marques, et al.
Published: (2018-10-01)

Obesogenic and diabetic effects of CD44 in mice are sexually dimorphic and dependent on genetic background
by: Melissa VerHague, et al.
Published: (2022-04-01)

Correlation of Soluble CD44 Expression in Saliva and CD44 Protein in Oral Leukoplakia Tissues
by: Ingrīda Čēma, et al.
Published: (2021-11-01)

Interplay between Podoplanin, CD44s and CD44v in Squamous Carcinoma Cells
by: Lucía Montero-Montero, et al.
Published: (2020-09-01)

CD44 and CD44v6 are Correlated with Gastric Cancer Progression and Poor Patient Prognosis: Evidence from 42 Studies
by: Min Fang, et al.
Published: (2016-11-01)

A Novel Anti-CD44 Variant 9 Monoclonal Antibody C<sub>44</sub>Mab-1 Was Developed for Immunohistochemical Analyses against Colorectal Cancers
by: Mayuki Tawara, et al.
Published: (2023-04-01)

Development of a Novel Anti-CD44 Variant 6 Monoclonal Antibody C<sub>44</sub>Mab-9 for Multiple Applications against Colorectal Carcinomas
by: Ryo Ejima, et al.
Published: (2023-02-01)

Prognostic Value of CD44 and Its Isoforms in Advanced Cancer: A Systematic Meta-Analysis With Trial Sequential Analysis
by: Susu Han, et al.
Published: (2019-02-01)

CD44 Glycosylation as a Therapeutic Target in Oncology
by: Chengcheng Liao, et al.
Published: (2022-07-01)

Development of a Novel Anti-CD44 Variant 4 Monoclonal Antibody C<sub>44</sub>Mab-108 for Immunohistochemistry
by: Hiroyuki Suzuki, et al.
Published: (2023-02-01)

A Novel Anti-CD44 Variant 3 Monoclonal Antibody C<sub>44</sub>Mab-6 Was Established for Multiple Applications
by: Hiroyuki Suzuki, et al.
Published: (2023-05-01)

The v8-10 variant isoform of CD44 is selectively expressed in the normal human colonic stem cell niche and frequently is overexpressed in colon carcinomas during tumor development
by: Bruce M. Boman, et al.
Published: (2023-12-01)

Development of a Novel Anti-CD44 Variant 5 Monoclonal Antibody C<sub>44</sub>Mab-3 for Multiple Applications against Pancreatic Carcinomas
by: Yuma Kudo, et al.
Published: (2023-04-01)

Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44
by: Gulimirerouzi Fnu, et al.
Published: (2021-05-01)

CD44 in Bladder Cancer
by: Jason Duex, et al.
Published: (2024-03-01)

Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity
by: Saniya Salathia, et al.
Published: (2023-04-01)

Development of a Novel Anti-CD44 Variant 7/8 Monoclonal Antibody, C<sub>44</sub>Mab-34, for Multiple Applications against Oral Carcinomas
by: Hiroyuki Suzuki, et al.
Published: (2023-04-01)

Multifunctional, CD44v6-Targeted ORMOSIL Nanoparticles Enhance Drugs Toxicity in Cancer Cells
by: Lucía Morillas-Becerril, et al.
Published: (2020-02-01)

Targeting the pentraxin 3/CD44 axis: A potential treatment for pulmonary fibrosis
by: Shia Vang, et al.
Published: (2023-02-01)

Characterization of CD44 intracellular domain interaction with RUNX2 in PC3 human prostate cancer cells
by: Linda T. Senbanjo, et al.
Published: (2019-07-01)

CD44 promotes hepatocellular carcinoma progression via upregulation of YAP
by: Jun Zhang, et al.
Published: (2021-11-01)

Expression analysis of CD44 isoforms S and V3, in patients with esophageal squamous cell carcinoma
by: Atena Mansouri, et al.
Published: (2015-04-01)

Evaluation of CD44s, CD44v6, CXCR2, CXCL1, and IL-1β in Benign and Malignant Tumors of Salivary Glands
by: Fonthip Laohavisudhi, et al.
Published: (2022-05-01)

A paclitaxel-hyaluronan conjugate (ONCOFID-P-B™) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the tumor microenvironment
by: Anna Tosi, et al.
Published: (2024-04-01)

CD44: A Multifunctional Mediator of Cancer Progression
by: Malak Hassn Mesrati, et al.
Published: (2021-12-01)

The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer
by: Nicola Cirillo
Published: (2023-10-01)

RNA-binding proteins regulating the CD44 alternative splicing
by: Diana Maltseva, et al.
Published: (2023-12-01)

Establishment of a Novel Anti-CD44 Variant 10 Monoclonal Antibody C<sub>44</sub>Mab-18 for Immunohistochemical Analysis against Oral Squamous Cell Carcinomas
by: Kenichiro Ishikawa, et al.
Published: (2023-06-01)

A Systematic Review to Clarify the Prognostic Values of CD44 and CD44+CD24- Phenotype in Triple-Negative Breast Cancer Patients: Lessons Learned and The Road Ahead
by: Mahdi Abdoli Shadbad, et al.
Published: (2021-08-01)

CD44/CD24 Expression in recurrent gastric cancer: a retrospective analysis
by: Yong Ching-Shya, et al.
Published: (2012-07-01)

CD44-Targeted Nanocarrier for Cancer Therapy
by: Prashant Kesharwani, et al.
Published: (2022-03-01)

Evaluation of the Correlation between CD44, Tumor Prognosis and the 5-Year Survival Rate in Patients with Oral Tongue SCC
by: Reza Kaboodkhani, et al.
Published: (2016-11-01)

Reduction-sensitive CD44 receptor-targeted hyaluronic acid derivative micelles for doxorubicin delivery
by: Yang YS, et al.
Published: (2018-07-01)

Hyaluronic Acid- Paclitaxel: Antitumor Efficacy against CD44(+) Human Ovarian Carcinoma Xenografts
by: Edmond Auzenne, et al.
Published: (2007-06-01)

CD44-Targeted Carriers: The Role of Molecular Weight of Hyaluronic Acid in the Uptake of Hyaluronic Acid-Based Nanoparticles
by: Enrica Chiesa, et al.
Published: (2022-01-01)

1,2,3,4,6-Penta-O-galloyl-β-D-glucose Inhibits CD44v3, a cancer stem cell marker, by regulating its transcription factor, in human pancreatic cancer cell line
by: Eun-Young Kim, et al.
Published: (2022-11-01)

Expression of MMP-14 and CD44 associated with proliferation of retinoblastoma cells
by: Hendrian D. Soebagjo, et al.
Published: (2019-06-01)

Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy
by: Patrycja K. Kruk, et al.
Published: (2023-05-01)

High Expression of CD44 Predicts a Poor Prognosis in Glioblastomas
by: Si D, et al.
Published: (2020-02-01)