Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Abstract Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a huge public health burden. Military personnel, compared with civilians, is exposed t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Military Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40779-023-00452-0 |
| _version_ | 1827956878050590720 |
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| author | Qian-Yun Guo Jia-Qi Yang Xun-Xun Feng Yu-Jie Zhou |
| author_facet | Qian-Yun Guo Jia-Qi Yang Xun-Xun Feng Yu-Jie Zhou |
| author_sort | Qian-Yun Guo |
| collection | DOAJ |
| description | Abstract Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a huge public health burden. Military personnel, compared with civilians, is exposed to more stress, a risk factor for heart diseases, making cardiovascular health management and treatment innovation an important topic for military medicine. So far, medical intervention can slow down cardiovascular disease progression, but not yet induce heart regeneration. In the past decades, studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury. Insights have emerged from studies in animal models and early clinical trials. Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease. In this review, we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury. |
| first_indexed | 2024-04-09T15:11:35Z |
| format | Article |
| id | doaj.art-358e8512b2da40629614133e4d645194 |
| institution | Directory Open Access Journal |
| issn | 2054-9369 |
| language | English |
| last_indexed | 2024-04-09T15:11:35Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj.art-358e8512b2da40629614133e4d6451942023-04-30T11:11:06ZengBMCMilitary Medical Research2054-93692023-04-0110111610.1186/s40779-023-00452-0Regeneration of the heart: from molecular mechanisms to clinical therapeuticsQian-Yun Guo0Jia-Qi Yang1Xun-Xun Feng2Yu-Jie Zhou3Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a huge public health burden. Military personnel, compared with civilians, is exposed to more stress, a risk factor for heart diseases, making cardiovascular health management and treatment innovation an important topic for military medicine. So far, medical intervention can slow down cardiovascular disease progression, but not yet induce heart regeneration. In the past decades, studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury. Insights have emerged from studies in animal models and early clinical trials. Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease. In this review, we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.https://doi.org/10.1186/s40779-023-00452-0Heart regenerationCardiac diseaseTherapeuticsSignaling mechanisms |
| spellingShingle | Qian-Yun Guo Jia-Qi Yang Xun-Xun Feng Yu-Jie Zhou Regeneration of the heart: from molecular mechanisms to clinical therapeutics Military Medical Research Heart regeneration Cardiac disease Therapeutics Signaling mechanisms |
| title | Regeneration of the heart: from molecular mechanisms to clinical therapeutics |
| title_full | Regeneration of the heart: from molecular mechanisms to clinical therapeutics |
| title_fullStr | Regeneration of the heart: from molecular mechanisms to clinical therapeutics |
| title_full_unstemmed | Regeneration of the heart: from molecular mechanisms to clinical therapeutics |
| title_short | Regeneration of the heart: from molecular mechanisms to clinical therapeutics |
| title_sort | regeneration of the heart from molecular mechanisms to clinical therapeutics |
| topic | Heart regeneration Cardiac disease Therapeutics Signaling mechanisms |
| url | https://doi.org/10.1186/s40779-023-00452-0 |
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