Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study
Background: Post-operative analgesia is a major problem associated with relatively short duration of action of spinal-anesthetics. Intrathecal adjuvants can prolong the duration of analgesia giving better success rate & patient satisfaction. Aims and Objectives: To assess the duration of post...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-04-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/42201 |
| _version_ | 1818745264538648576 |
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| author | BK Girish BP Manjula HM Akshay KG Shivakumar D Navakanth B Nandi Vinayaka |
| author_facet | BK Girish BP Manjula HM Akshay KG Shivakumar D Navakanth B Nandi Vinayaka |
| author_sort | BK Girish |
| collection | DOAJ |
| description | Background: Post-operative analgesia is a major problem associated with relatively short duration of action of spinal-anesthetics. Intrathecal adjuvants can prolong the duration of analgesia giving better success rate & patient satisfaction.
Aims and Objectives: To assess the duration of postoperative analgesia with intrathecal bupivacaine supplemented with either nalbuphine or clonidine as adjuvants and also to assess the time of onset, maximum level and duration of sensory and motor blockade, and any postoperative complications.
Materials and Methods: Following institutional ethical committee approval 60 patients scheduled for elective infra umbilical surgeries duration of less than 2 hours, under spinal anesthesia, were included in this prospective randomized interventional study. Patients were randomly allocated to one of two groups into Group-N received 2.5 ml of 0.5 % hyperbaric bupivacine + 0.5ml of nalbuphine (0.4mg). Group-C received 2.5 ml of 0.5% hyperbaric bupivacine + 0.5 ml of clonidine (30 μg). The onset of sensory and motor blockade, duration of sensory and motor blockade, two-segment regression time from highest level of sensory blockade, and duration of analgesia was recorded.
Results: Total duration of postoperative analgesia was significantly higher in group-C(351.00±31.00 min) than in group-N(256.00±8.14 min). Though the mean time for onset of sensory and motor block among both groups was not significantly different, the mean time for complete sensory and motor recovery was significantly longer in Group-C than Group-N.
Conclusion: Intrathecal clonidine has more prolonged analgesia and motor blockade compared to nalbuphine, and hence clonidine can be preferred over nalbuphine as an intrathecal adjuvant. |
| first_indexed | 2024-12-18T02:57:26Z |
| format | Article |
| id | doaj.art-358f02cdb79d4b2cb95e2a5d25a53fea |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-18T02:57:26Z |
| publishDate | 2022-04-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-358f02cdb79d4b2cb95e2a5d25a53fea2022-12-21T21:23:20ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-04-011343137https://doi.org/10.3126/ajms.v13i4.42201Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective studyBK Girish 0https://orcid.org/0000-0002-3734-6385BP Manjula 1https://orcid.org/0000-0002-4510-0430HM Akshay 2https://orcid.org/0000-0001-5915-6841KG Shivakumar 3https://orcid.org/0000-0003-4245-0176D Navakanth 4https://orcid.org/0000-0002-5399-1472B Nandi Vinayaka 5https://orcid.org/0000-0002-2897-3803Associate Professor, Department of Anaesthesiology, JSS Medical College and Hospital, Mysuru, Karnataka, India Professor, Department of Anaesthesiology, JSS Medical College and Hospital, Mysuru, Karnataka, India Assistant Professor, Department of Anaesthesiology, JSS Medical College and Hospital, Mysuru, Karnataka, India Senior Resident, Department of Anaesthesiology, JSS Medical College and Hospital, Mysuru, Karnataka, India Postgraduate, Department of Anaesthesiology, JSS Medical College and Hospital, Mysuru, Karnataka, India Postgraduate, Department of Anaesthesiology, JSS Medical College and Hospital, Mysuru, Karnataka, India Background: Post-operative analgesia is a major problem associated with relatively short duration of action of spinal-anesthetics. Intrathecal adjuvants can prolong the duration of analgesia giving better success rate & patient satisfaction. Aims and Objectives: To assess the duration of postoperative analgesia with intrathecal bupivacaine supplemented with either nalbuphine or clonidine as adjuvants and also to assess the time of onset, maximum level and duration of sensory and motor blockade, and any postoperative complications. Materials and Methods: Following institutional ethical committee approval 60 patients scheduled for elective infra umbilical surgeries duration of less than 2 hours, under spinal anesthesia, were included in this prospective randomized interventional study. Patients were randomly allocated to one of two groups into Group-N received 2.5 ml of 0.5 % hyperbaric bupivacine + 0.5ml of nalbuphine (0.4mg). Group-C received 2.5 ml of 0.5% hyperbaric bupivacine + 0.5 ml of clonidine (30 μg). The onset of sensory and motor blockade, duration of sensory and motor blockade, two-segment regression time from highest level of sensory blockade, and duration of analgesia was recorded. Results: Total duration of postoperative analgesia was significantly higher in group-C(351.00±31.00 min) than in group-N(256.00±8.14 min). Though the mean time for onset of sensory and motor block among both groups was not significantly different, the mean time for complete sensory and motor recovery was significantly longer in Group-C than Group-N. Conclusion: Intrathecal clonidine has more prolonged analgesia and motor blockade compared to nalbuphine, and hence clonidine can be preferred over nalbuphine as an intrathecal adjuvant.https://www.nepjol.info/index.php/AJMS/article/view/42201adjuvantsclonidinenalbuphinespinal anesthesia |
| spellingShingle | BK Girish BP Manjula HM Akshay KG Shivakumar D Navakanth B Nandi Vinayaka Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study Asian Journal of Medical Sciences adjuvants clonidine nalbuphine spinal anesthesia |
| title | Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study |
| title_full | Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study |
| title_fullStr | Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study |
| title_full_unstemmed | Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study |
| title_short | Comparison of intrathecal Nalbuphine and Clonidine as adjuvants to Bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients – a prospective study |
| title_sort | comparison of intrathecal nalbuphine and clonidine as adjuvants to bupivacaine heavy for spinal anesthesia in elective infraumbilical surgeries in adult patients a prospective study |
| topic | adjuvants clonidine nalbuphine spinal anesthesia |
| url | https://www.nepjol.info/index.php/AJMS/article/view/42201 |
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