Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment

Increasing evidence implicates decreased energy metabolism and mitochondrial dysfunctions among the earliest pathogenic events of Alzheimer’s disease (AD). However, the molecular mechanisms underlying bioenergetic dysfunctions in AD remain, to date, largely unknown. In this work, we analyzed transcr...

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Bibliographic Details
Main Authors: Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Valentina Latina, Pietro Calissano, Giuseppina Amadoro, Sebastiano Cavallaro
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cells
Subjects:
transcriptomic
RNA-seq
GSEA
systems biology
tau immunotherapy
Tg2576
Online Access:https://www.mdpi.com/2073-4409/12/18/2254

Internet

https://www.mdpi.com/2073-4409/12/18/2254

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