Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy
<i>Highlights:</i> Sarcopenia is frequent in patients treated with radiation therapy (RT) or radiochemotherapy (RTCT) for head and neck squamous cell carcinomas. Sarcopenia is associated with poor disease-free survival and overall survival outcomes. Sarcopenia is not associated with a hi...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/4/753 |
| _version_ | 1797396837961826304 |
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| author | Sébastien Thureau Lucie Lebret Justine Lequesne Marine Cabourg Simon Dandoy Céline Gouley Laureline Lefebvre Romain Mallet Sorina-Dana Mihailescu Cristian Moldovan Olivier Rigal Ovidiu Veresezan Romain Modzewelski Florian Clatot |
| author_facet | Sébastien Thureau Lucie Lebret Justine Lequesne Marine Cabourg Simon Dandoy Céline Gouley Laureline Lefebvre Romain Mallet Sorina-Dana Mihailescu Cristian Moldovan Olivier Rigal Ovidiu Veresezan Romain Modzewelski Florian Clatot |
| author_sort | Sébastien Thureau |
| collection | DOAJ |
| description | <i>Highlights:</i> Sarcopenia is frequent in patients treated with radiation therapy (RT) or radiochemotherapy (RTCT) for head and neck squamous cell carcinomas. Sarcopenia is associated with poor disease-free survival and overall survival outcomes. Sarcopenia is not associated with a higher rate of treatment-related toxicity. <i>Background:</i> Sarcopenia occurs frequently with the diagnosis of head and neck squamous cell carcinoma (HNSCC). We aimed to assess the impact of sarcopenia on survival among HNSCC patients treated with radiotherapy (RT) or radiochemotherapy (RTCT). <i>Methods:</i> Patients treated between 2014 and 2018 by RT or RTCT with curative intent were prospectively included (NCT02900963). Optimal nutritional support follow-up, including weekly consultation with a dietician and an oncologist and daily weight monitoring, was performed. Sarcopenia was determined by measuring the skeletal muscles at the L3 vertebra on the planning CT scan for radiotherapy. For each treatment group (RT or RTCT), we assessed the prognostic value of sarcopenia for disease-free survival (DFS) and overall survival (OS) and its impact on treatment-related toxicity. <i>Results:</i> Two hundred forty-three HNSCC patients were included: 116 were treated by RT and 127 were treated by RTCT. Before radiotherapy, eight (3.3%) patients were considered malnourished according to albumin, whereas 88 (36.7%) patients were sarcopenic. Overall, sarcopenia was associated with OS and DFS in a multivariate analysis (HR 1.9 [1.1–3.25] and 1.7 [1.06–2.71], respectively). It was similar for patients treated with RT (HR 2.49 [1.26–4.9] for DFS and 2.24 [1.03–4.86] for OS), whereas for patients treated with RTCT sarcopenia was significantly associated with OS and DFS in univariate analysis only. Sarcopenia was not related to higher treatment-related toxicity. <i>Conclusions:</i> Pretherapeutic sarcopenia remains frequent and predicts OS and DFS for non-frail patients treated with curative intent and adequate nutritional support. |
| first_indexed | 2024-03-09T00:58:19Z |
| format | Article |
| id | doaj.art-358fba129e3e49e9b179cdd96545d809 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T00:58:19Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-358fba129e3e49e9b179cdd96545d8092023-12-11T16:45:48ZengMDPI AGCancers2072-66942021-02-0113475310.3390/cancers13040753Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or RadiochemotherapySébastien Thureau0Lucie Lebret1Justine Lequesne2Marine Cabourg3Simon Dandoy4Céline Gouley5Laureline Lefebvre6Romain Mallet7Sorina-Dana Mihailescu8Cristian Moldovan9Olivier Rigal10Ovidiu Veresezan11Romain Modzewelski12Florian Clatot13Department of Radiation Oncology, Henri Becquerel Cancer Center & QuantIF—LITIS [EA (Equipe d’Accueil) 4108], 76038 Rouen, FranceDepartment of Radiation Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Statistics and Clinical Research Unit, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Medical Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Radiation Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Supportive Cancer, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Radiation Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Radiation Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Statistics and Clinical Research Unit, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Medical Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Medical Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Radiation Oncology, Henri Becquerel Cancer Center, 76038 Rouen, FranceDepartment of Nuclear Medicine, Henri Becquerel Cancer Center & QuantIF—LITIS [EA (Equipe d’Accueil) 4108—FR CNRS 3638], Faculty of Medicine, University of Rouen, 76130 Rouen, FranceDepartment of Medical Oncology, Henri Becquerel Cancer Center, 76038 Rouen, France<i>Highlights:</i> Sarcopenia is frequent in patients treated with radiation therapy (RT) or radiochemotherapy (RTCT) for head and neck squamous cell carcinomas. Sarcopenia is associated with poor disease-free survival and overall survival outcomes. Sarcopenia is not associated with a higher rate of treatment-related toxicity. <i>Background:</i> Sarcopenia occurs frequently with the diagnosis of head and neck squamous cell carcinoma (HNSCC). We aimed to assess the impact of sarcopenia on survival among HNSCC patients treated with radiotherapy (RT) or radiochemotherapy (RTCT). <i>Methods:</i> Patients treated between 2014 and 2018 by RT or RTCT with curative intent were prospectively included (NCT02900963). Optimal nutritional support follow-up, including weekly consultation with a dietician and an oncologist and daily weight monitoring, was performed. Sarcopenia was determined by measuring the skeletal muscles at the L3 vertebra on the planning CT scan for radiotherapy. For each treatment group (RT or RTCT), we assessed the prognostic value of sarcopenia for disease-free survival (DFS) and overall survival (OS) and its impact on treatment-related toxicity. <i>Results:</i> Two hundred forty-three HNSCC patients were included: 116 were treated by RT and 127 were treated by RTCT. Before radiotherapy, eight (3.3%) patients were considered malnourished according to albumin, whereas 88 (36.7%) patients were sarcopenic. Overall, sarcopenia was associated with OS and DFS in a multivariate analysis (HR 1.9 [1.1–3.25] and 1.7 [1.06–2.71], respectively). It was similar for patients treated with RT (HR 2.49 [1.26–4.9] for DFS and 2.24 [1.03–4.86] for OS), whereas for patients treated with RTCT sarcopenia was significantly associated with OS and DFS in univariate analysis only. Sarcopenia was not related to higher treatment-related toxicity. <i>Conclusions:</i> Pretherapeutic sarcopenia remains frequent and predicts OS and DFS for non-frail patients treated with curative intent and adequate nutritional support.https://www.mdpi.com/2072-6694/13/4/753radiotherapyradiochemotherapysarcopeniahead and neck squamous cell carcinomas |
| spellingShingle | Sébastien Thureau Lucie Lebret Justine Lequesne Marine Cabourg Simon Dandoy Céline Gouley Laureline Lefebvre Romain Mallet Sorina-Dana Mihailescu Cristian Moldovan Olivier Rigal Ovidiu Veresezan Romain Modzewelski Florian Clatot Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy Cancers radiotherapy radiochemotherapy sarcopenia head and neck squamous cell carcinomas |
| title | Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy |
| title_full | Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy |
| title_fullStr | Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy |
| title_full_unstemmed | Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy |
| title_short | Prospective Evaluation of Sarcopenia in Head and Neck Cancer Patients Treated with Radiotherapy or Radiochemotherapy |
| title_sort | prospective evaluation of sarcopenia in head and neck cancer patients treated with radiotherapy or radiochemotherapy |
| topic | radiotherapy radiochemotherapy sarcopenia head and neck squamous cell carcinomas |
| url | https://www.mdpi.com/2072-6694/13/4/753 |
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